3'-Methoxy-4'-aminoflavone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3'-Methoxy-4'-aminoflavone
• 英文别名: 2-(4-amino-3-methoxyphenyl)chromen-4-one
• 化学式: C₁₆H₁₃NO₃
• 分子量: 267.28
• InChiKey: DOCHWYMAUDTWFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Methods and compositions for treating respiratory pathologies
  申请人：——

  公开号：US20030125321A1

  公开（公告）日：2003-07-03

  The present application relates to compositions and methods for treating respiratory pathologies. It equally concerns compositions and methods allowing regulation of the paracellular permeability of the pulmonary epithelium. The compositions and methods of the invention are based in particular on the use of agents or conditions modulating the tension of the cytoskeleton of pulmonary epithelial cells, particularly enterocytes. The invention may be used for preventive or curative treatment of various pathologies, such as asthma, allergies, obstructive diseases, etc., in mammals, particularly humans.

  本申请涉及治疗呼吸系统疾病的组合物和方法。它同样涉及可调节肺上皮细胞旁通透性的组合物和方法。本发明的组合物和方法尤其基于使用调节肺上皮细胞，特别是肠细胞的细胞骨架张力的制剂或条件。本发明可用于预防或治疗哺乳动物，特别是人类的各种病症，如哮喘、过敏、阻塞性疾病等。
• Method and compositions for treating respiratory pathologies
  申请人：Bueno Lionel

  公开号：US20050019314A1

  公开（公告）日：2005-01-27

  The present application relates to compositions and methods for treating respiratory pathologies. It equally concerns compositions and methods allowing regulation of the paracellular permeability of the pulmonary epithelium. The compositions and methods of the invention are based in particular on the use of agents or conditions modulating the tension of the cytoskeleton of pulmonary epithelial cells, particularly enterocytes. The invention may be used for preventive or curative treatment of various pathologies, such as asthma, allergies, obstructive diseases, etc., in mammals, particularly humans.

  本申请涉及治疗呼吸系统疾病的组合物和方法。它同样涉及可调节肺上皮细胞旁通透性的组合物和方法。本发明的组合物和方法尤其基于使用调节肺上皮细胞，特别是肠细胞的细胞骨架张力的制剂或条件。本发明可用于预防或治疗哺乳动物，特别是人类的各种病症，如哮喘、过敏、阻塞性疾病等。
• Compositions for treating digestive functional pathologies
  申请人：Bueno Lionel

  公开号：US20050054577A1

  公开（公告）日：2005-03-10

  The invention concerns compositions and methods for treating intestinal pathologies. The invention also concerns compositions and methods enabling the regulation of paracellular permeability of the intestinal epithelium. The inventive compositions and methods are based in particular on the use of agents or conditions modulating the opening of tight junctions of the intestinal epithelium. The invention can be used for preventive or curative treatment of various pathologies, such as intestinal functional disorders (IFD) resulting in hyperalgesia and particularly irritable bowel syndrome (IBS), in mammals, particularly humans.

  本发明涉及治疗肠道疾病的组合物和方法。本发明还涉及能够调节肠上皮细胞旁通透性的组合物和方法。本发明的组合物和方法尤其基于使用调节肠上皮细胞紧密连接开放的制剂或条件。本发明可用于预防或治疗哺乳动物，尤其是人类的各种病症，如导致痛觉减退的肠功能紊乱（IFD），特别是肠易激综合征（IBS）。
• Protease Inhibitors For the Treatment of Digestive Pathologies
  申请人：Bueno Lionel

  公开号：US20080286355A1

  公开（公告）日：2008-11-20

  The invention relates to compositions and methods for the treatment of intestinal pathologies. The invention also relates to compositions and methods which can be used to regulate the paracellular permeability of the intestinal epithelium. The inventive compositions and methods are based in particular on the use of protease inhibitors which modulate the opening of the tight junctions of the intestinal epithelium. The invention can be used for preventive or curative treatment of different pathologies, such as functional digestive disorders (FGID), in particular intestinal functional disorders (IFD) causing hyperalgesia and in particular irritable bowel syndrome (IBS), in mammals, particularly humans.
• US7452877B2
  申请人：——

  公开号：US7452877B2

  公开（公告）日：2008-11-18