2-Methyl-5-phenyl-1,3-thiazol-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Methyl-5-phenyl-1,3-thiazol-4-amine
• 化学式: C₁₀H₁₀N₂S
• mdl: MFCD12026900
• 分子量: 190.27
• InChiKey: HGQCFPLZGCHBBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• IAP BINDING COMPOUNDS
  申请人：Lundorf Mikkel Dybro

  公开号：US20110230419A1

  公开（公告）日：2011-09-22

  The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates or prodrugs thereof, that bind to Inhibitor of Apoptosis Proteins (IAPs). The compounds of the invention may be used as diagnostic and therapeutic agents in the treatment of proliferative diseases, such as cancer, for promoting apoptosis in proliferating cells, and for sensitizing cells to inducers of apoptosis. The present invention furthermore provides a polymeric compound of formulas (VI) or (VII), comprising either at least two monomeric units of compounds of formula (I), or at least one monomeric unit of a compound of formula (I) and an entity E. The present invention further relates to pharmaceutical compositions comprising said compounds of formulas (I), (VI), and (VII) and the use of said compounds in medicine.

  本发明涉及式(I)的化合物，或其药学上可接受的盐、溶剂化合物或前药，其与凋亡抑制蛋白（IAPs）结合。本发明的化合物可用作诊断和治疗增生性疾病，例如癌症，促进增殖细胞的凋亡，并使细胞对凋亡诱导剂敏感。本发明还提供式(VI)或(VII)的聚合物化合物，其中包括至少两个式(I)的单体单位，或至少一个式(I)的单体单位和一个实体E。本发明还涉及包含上述化合物的药物组合物，以及在医学中使用上述化合物的用途。
• INHIBITORS OF IAP
  申请人：Cohen Frederick

  公开号：US20120202750A1

  公开（公告）日：2012-08-09

  The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R 1 , R 2 , R 3 , R 4 , R 4 ′, R 5 , R 5 ′, R 6 and R 6 ′ are as described herein.

  该发明提供了新型IAP抑制剂，可用作治疗恶性肿瘤的治疗剂，其中化合物具有一般式I：其中X、Y、A、R1、R2、R3、R4、R4'、R5、R5'、R6和R6'如本文所述。
• AZA-BRIDGED-RING COMPOUND
  申请人：Astellas Pharma Inc.

  公开号：EP2119716A1

  公开（公告）日：2009-11-18

  [PROBLEMS] Provided is a compound which has an antagonistic action on a muscarinic M3 receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like. [MEANS FOR SOLVING PROBLEMS] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic M3 receptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic M3 receptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic M3 receptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.

  [问题]本发明提供了一种化合物，该化合物对毒蕈碱 M3 受体具有拮抗作用，可用作慢性阻塞性肺病 （COPD）、哮喘等炎症疾病的预防和/或治疗剂的活性成分。 [解决问题的方法]本发明者对一种对毒蕈碱类 M3 受体的结合具有拮抗作用的化合物进行了研究，他们发现一种杂环桥环化合物或其盐对毒蕈碱类 M3 受体的结合具有拮抗作用，从而完成了本发明。本发明的杂环桥环化合物对毒蕈碱类 M3 受体的结合具有拮抗作用，可用作慢性阻塞性肺病（COPD）、哮喘等炎症疾病的预防和/或治疗剂。
• US8980837B2
  申请人：——

  公开号：US8980837B2

  公开（公告）日：2015-03-17