Boc-(Ala-Hmb)2-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: Boc-(Ala-Hmb)2-OH
• 英文别名: 3-methyl-2-[2-[[3-methyl-2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyloxy]butanoyl]amino]propanoyloxy]butanoic acid
• 化学式: C₂₁H₃₆N₂O₉
• 分子量: 460.5
• InChiKey: IPICFSFUAKDZEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  32
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  157
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Methods for treating diseases related to the wnt pathway
  申请人：Sandia Corporation

  公开号：US10624949B1

  公开（公告）日：2020-04-21

  The present invention relates to methods for treating a disease, in which the disease arises from dysregulation of the Wnt signaling pathway. In some instances, the disease can be treated by administering a Wnt pathway inhibitory compound. In other instances, the method optionally includes conducting a genome-wide screening to determine one or more genes resulting in a reduced disease state and then identifying the gene(s) as being involved in the Wnt signaling pathway.

  本发明涉及治疗疾病的方法，其中疾病是由 Wnt 信号通路失调引起的。在某些情况下，可以通过施用抑制 Wnt 通路的化合物来治疗疾病。在其他情况下，该方法可选地包括进行全基因组筛选，以确定导致疾病状态降低的一个或多个基因，然后确定这些基因参与Wnt信号通路。
• Inhibitors of cancer invasion, attachment, and/or metastasis
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US11008325B2

  公开（公告）日：2021-05-18

  Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.

  本文特别提供了与 MDA-9/Syntenin（辛迪卡结合蛋白：SDCBP）的 PDZ1 结构域结合从而抑制 MDA-9/Syntenin 活性的组合物及其使用方法。本文提供的组合物和方法可用于治疗癌症和预防癌症转移，特别是在 MDA-9/Syntenin 表达增加的癌症中。
• Compositions and Methods for Modulating Neuron Degeneration and Neuron Guidance
  申请人：ZOU Yimin

  公开号：US20110065645A1

  公开（公告）日：2011-03-17

  Methods for inhibiting degeneration of a neuron, methods of treating a neurodegenerative disease, methods for promoting degeneration of a neuron are provided, methods for modulating neuron cell guidance of a neuron, as well as compounds useful in the methods of the invention, such as a Wnt compound, a Fzd3 dephosphorylating agent, a Fzd3 phosphorylating agent, or a SHH compound as disclosed herein.
• INHIBITORS OF CANCER INVASION, ATTACHMENT, AND/OR METASTASIS
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US20190263824A1

  公开（公告）日：2019-08-29

  Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.