3-[4-[6-(3-Imino-3-morpholin-4-ylprop-1-enyl)imidazo[1,2-a]pyridin-2-yl]phenyl]-1-morpholin-4-ylprop-2-en-1-imine;hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[4-[6-(3-Imino-3-morpholin-4-ylprop-1-enyl)imidazo[1,2-a]pyridin-2-yl]phenyl]-1-morpholin-4-ylprop-2-en-1-imine;hydrochloride
• 化学式: C₂₇H₃₀N₆O₂*3ClH
• 分子量: 579.957
• InChiKey: WBZXXFWSIZBNKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.07
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  89.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(4-Formylphenyl)imidazo[1,2-a]pyridine-6-carbaldehyde 在 正丁基锂 、 三甲基铝 作用下， 反应 46.5h， 生成 3-[4-[6-(3-Imino-3-morpholin-4-ylprop-1-enyl)imidazo[1,2-a]pyridin-2-yl]phenyl]-1-morpholin-4-ylprop-2-en-1-imine;hydrochloride
  参考文献：
  名称：

  Bis-Cationic Heteroaromatics as Macrofilaricides:  Synthesis of Bis-Amidine and Bis-Guanylhydrazone Derivatives of Substituted Imidazo[1,2-a]pyridines

  摘要：

  A series of guanylhydrazone, amidine, and hydrazone derivatives of 2-phenylimidazo[1,2-a]pyridine have been prepared and evaluated for macrofilarial activity against Acanthocheilonema viteae and Brugia pahangi in jirds. Compounds with 4',6-bis-substitution by cyclic guanylhydrazone groups show activity. 4',6-Bis-amidines show some activity but are more toxic; 4'- or 6-monosubstituted compounds are inactive. 2,6-Bis-substituted compounds lacking the phenyl ring are inactive. 4',6-Bis-substituted compounds having additional double bonds inserted between the heterocyclic ring and the phenyl ring or between the substituent and the ring system show reduced activity.

  DOI：

  10.1021/jm9803368