Dimethyl 2,6-dimethyl-4-(5-nitroimidazo[2,1-b][1,3]thiazol-6-yl)-1,4-dihydropyridine-3,5-dicarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Dimethyl 2,6-dimethyl-4-(5-nitroimidazo[2,1-b][1,3]thiazol-6-yl)-1,4-dihydropyridine-3,5-dicarboxylate
• 化学式: C₁₆H₁₆N₄O₆S
• 分子量: 392.392
• InChiKey: BFSNUBUISVVEOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  156
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  5-nitro-6-methylimidazo<2,1-b>thiazole 在 哌啶 、 ammonium hydroxide 、 sodium periodate 、 四氧化锇 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 反应 90.0h， 生成 Dimethyl 2,6-dimethyl-4-(5-nitroimidazo[2,1-b][1,3]thiazol-6-yl)-1,4-dihydropyridine-3,5-dicarboxylate
  参考文献：
  名称：

  Dihydropyridines bearing an imidazo[2,1-b]thiazole system

  摘要：

  This paper reports the synthesis of imidazo[2,1-b]thiazoles, bearing a dihydropyridine ring at the 5 or 6 position, which were tested for antiarrhythmic, inotropic and chronotropic activities. Nine of the ten compounds bearing double bond at the 2,3 position and the same dihydropyridine as nifedipine at the 5 position, were antiarrhythmic; moreover one of them (bearing a methyl group at the 2 position) was devoid of negative inotropic activity.

  DOI：

  10.1016/s0223-5234(97)87542-3

文献信息

• Dihydropyridines bearing an imidazo[2,1-b]thiazole system
  作者：A Andreani、A Leoni、M Rambaldi、A Locatelli、R Bossa、I Galatulas、M Chiericozzi、M Bissoli

  DOI：10.1016/s0223-5234(97)87542-3

  日期：1997.1

  This paper reports the synthesis of imidazo[2,1-b]thiazoles, bearing a dihydropyridine ring at the 5 or 6 position, which were tested for antiarrhythmic, inotropic and chronotropic activities. Nine of the ten compounds bearing double bond at the 2,3 position and the same dihydropyridine as nifedipine at the 5 position, were antiarrhythmic; moreover one of them (bearing a methyl group at the 2 position) was devoid of negative inotropic activity.