4-methyl-4H-benzo[b]quinolizine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢异喹啉
• 英文名称: 4-methyl-4H-benzo[b]quinolizine
• 化学式: C₁₄H₁₃N
• 分子量: 195.26
• InChiKey: ZNYGFIOXZCMWCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Novel dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
  申请人：Patton Wayne Forrest

  公开号：US20110130305A1

  公开（公告）日：2011-06-02

  Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.

  提供了染料和组合物，这些染料和组合物在许多应用中非常有用，例如检测和监测蛋白质聚集、蛋白质聚集的动力学研究、神经原纤维样斑块分析、评估蛋白质配方稳定性、蛋白质热稳定性位移测定和分子伴侣活性分析。这些染料和组合物也可作为核酸和蛋白质检测中的探针。
• [EN] NOVEL DYES FOR THE DETECTION OR QUANTIFICATION OF DESIRABLE TARGET MOLECULES<br/>[FR] NOUVEAUX COLORANTS POUR LA DÉTECTION OU LA QUANTIFICATION DE MOLÉCULES CIBLES SOUHAITABLES
  申请人：ENZO LIFE SCIENCES INC

  公开号：WO2009014513A1

  公开（公告）日：2009-01-29

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质和核酸。所提供的染料可在溶液中自由使用，染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料连接到将结合到所需目标分子的探针上。本发明的新型染料经过改性以提供有益性能。
• Methods for detecting the presence, location or quantity of targets using novel dyes
  申请人：Xiang Yuejun

  公开号：US20100041020A1

  公开（公告）日：2010-02-18

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，例如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料连接到将结合到所需目标分子的探针上。本发明的新型染料已通过添加带电和极性基团进行改性，以提供有益的性质。
• Novel fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
  申请人：Pande Praveen

  公开号：US20100068752A1

  公开（公告）日：2010-03-18

  The present invention provides dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes provided in this invention can comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been substituted with specific groups to provide beneficial properties.

  本发明提供染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质、核酸和细胞器。提供可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号产生。本发明提供的染料可以包括可用于将染料附着到将结合到所需目标分子的探针上的反应性基团。本发明的新型染料已经用特定的基团取代，以提供有益的特性。
• Autophagy and phospholipidosis pathway assays
  申请人：Patton Wayne Forrest

  公开号：US20100093004A1

  公开（公告）日：2010-04-15

  Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.

  提供了用于检测和监测自噬和磷脂质沉积病的试验，包括溶酶体贮积病的进展。药物和治疗方法可以监测在溶酶体贮积病条件下的有效性。药物候选和疑似有毒物质也可以筛选对细胞、组织和器官的毒性。还提供了区分磷脂质沉积激活剂和自噬通路干扰剂的方法。