NSC-310342

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: NSC-310342
• 英文别名: 3-p-Chlorphenyl-5-(amidinomercaptomethyl)-1,2,4-oxadiazol；(3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl imidothiocarbamate；[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl carbamimidothioate
• 化学式: C₁₀H₉ClN₄OS
• mdl: MFCD20774956
• 分子量: 268.727
• InChiKey: FOAONBQCGRKHOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• REL INHIBITORS AND METHODS OF USE THEREOF
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20140066486A1

  公开（公告）日：2014-03-06

  This invention provides REL inhibitors which interfere with the DNA binding capacity of a REL protein. Additionally this invention provides methods of treating, abrogating, or preventing diseases which respond with a positive clinical score to a REL inhibitor. Methods of identifying REL inhibitor based on a REL protein three dimensional model are described.
• US8507546B2
  申请人：——

  公开号：US8507546B2

  公开（公告）日：2013-08-13