N-carbobenzoxy-α-isobutoxyglycine isobutyl ester | 138296-14-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-carbobenzoxy-α-isobutoxyglycine isobutyl ester
• 英文别名: 2-methylpropyl N-(benzyloxycarbonyl)-2-(2-methylpropoxyl)glycinate；2-Methylpropyl 2-(2-methylpropoxy)-2-(phenylmethoxycarbonylamino)acetate
• CAS: 138296-14-7
• 化学式: C₁₈H₂₇NO₅
• 分子量: 337.416
• InChiKey: FYIQQVBIODSPDX-UHFFFAOYSA-N

物化性质

• 沸点：
  462.1±45.0 °C(Predicted)
• 密度：
  1.086±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-carbobenzoxy-α-isobutoxyglycine isobutyl ester 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以89%的产率得到N-carbobenzoxy-α-isobutoxyglycine
  参考文献：
  名称：

  Preparation of Protected α-Alkoxyglycines

  摘要：

  N-Carbobenzoxy-alpha-alkoxyglycine esters were synthesized by H2SO4-catalyzed O-alkylation of N-carbobenzoxy-alpha-hydroxyglycine and also by base treatment of N-carbobenzoxy-N-chloroglycine methyl ester in the corresponding alcohol. Saponification of the protected alpha-alkoxyglycines gave free acids which can be used for the synthesis of alpha-alkoxyglycine residue-containing peptides.

  DOI：

  10.1080/00397919608003521
• 作为产物：
  描述：

  CBZ-甘氨酸甲酯 在 次氯酸叔丁酯 、 sodium isobutoxide 作用下， 以 甲醇 为溶剂， 反应 17.0h， 生成 N-carbobenzoxy-α-isobutoxyglycine isobutyl ester
  参考文献：
  名称：

  Preparation of Protected α-Alkoxyglycines

  摘要：

  N-Carbobenzoxy-alpha-alkoxyglycine esters were synthesized by H2SO4-catalyzed O-alkylation of N-carbobenzoxy-alpha-hydroxyglycine and also by base treatment of N-carbobenzoxy-N-chloroglycine methyl ester in the corresponding alcohol. Saponification of the protected alpha-alkoxyglycines gave free acids which can be used for the synthesis of alpha-alkoxyglycine residue-containing peptides.

  DOI：

  10.1080/00397919608003521

文献信息

• Renin inhibitors
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0427939A2

  公开（公告）日：1991-05-22

  Renin inhibiting compounds containing a single a-amino acid of the formula: and analogs thereof which inhibit the substrate-cleaving acting of renin, pharmaceutical compositions containing these compounds, processes for producing the compounds and methods of treating hypertension which employ the novel renin inhibitors.

  含有单个式 a-氨基酸的肾素抑制化合物： 及其类似物，可抑制肾素的底物清除作用；含有这些化合物的药物组合物；生产这些化合物的工艺；以及采用新型肾素抑制剂治疗高血压的方法。
• US5104869A
  申请人：——

  公开号：US5104869A

  公开（公告）日：1992-04-14
• Preparation of Protected α-Alkoxyglycines
  作者：Masao Kawai、Kouji Hosoda、Yoshimasa Omori、Keiichi Yamada、Shoko Hayakawa、Hatsuo Yamamura、Yasuo Butsugan

  DOI：10.1080/00397919608003521

  日期：1996.4

  N-Carbobenzoxy-alpha-alkoxyglycine esters were synthesized by H2SO4-catalyzed O-alkylation of N-carbobenzoxy-alpha-hydroxyglycine and also by base treatment of N-carbobenzoxy-N-chloroglycine methyl ester in the corresponding alcohol. Saponification of the protected alpha-alkoxyglycines gave free acids which can be used for the synthesis of alpha-alkoxyglycine residue-containing peptides.