Fluconazole & Flucytosine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Fluconazole & Flucytosine
• 英文别名: 6-amino-5-fluoro-1H-pyrimidin-2-one;2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
• 化学式: C17H16F3N9O2
• 分子量: 435.4
• InChiKey: BTCCYWBZVBMIGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.23
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Use Of 5,6-Dimethylxanthenone-4-Acetic Acid as an Antimicrobial Agent
  申请人：Vogel Stefanie N.

  公开号：US20080114021A1

  公开（公告）日：2008-05-15

  The invention relates to the areas of therapeutics, pharmaceuticals, drug discovery, and immunotherapy. More specifically, the present invention relates to methods of stimulating the immune system through the administration of flavone acetic acid [FAA] analogues, and in particular, the flavone acetic acid analogue, 5,6-dimethylxanthenone-4-acetic acid (DMXAA) so as to comprise an antimicrobial therapeutic agent for the treatment of viral, fungal, bacterial or parasitic infections in humans and non-human animals. The invention is especially suitable for use in a process of treating and preventing infection by viruses (for example, rhinoviruses, enteroviruses, and influenza viruses, etc.) and bacteria (especially intracellular bacterial pathogens such as Francisella tularensis ).
• Use of 5,6-Dimethylxanthenone-4-Acetic Acid as an Antiviral Agent
  申请人：Vogel Stefanie N.

  公开号：US20110218239A1

  公开（公告）日：2011-09-08

  The invention relates to the areas of therapeutics, pharmaceuticals, drug discovery, and immunotherapy. More specifically, the present invention relates to methods of stimulating the immune system through the administration of flavone acetic acid [FAA] analogues, and in particular, the flavone acetic acid analogue, 5,6-dimethylxanthenone-4-acetic acid (DMXAA) so as to comprise an antimicrobial therapeutic agent for the treatment of viral infections of DNA and RNA viruses in humans and non-human animals. The invention is especially suitable for use in a process of treating and preventing infection by, for example, rhinoviruses, enteroviruses, and influenza viruses.
• US8957108B2
  申请人：——

  公开号：US8957108B2

  公开（公告）日：2015-02-17
• [EN] USE OF 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID AS AN ANTIMICROBIAL AGENT<br/>[FR] UTILISATION DE L'ACIDE 5,6-DIMÉTHYLXANTHÉNONE-4-ACÉTIQUE EN TANT QU'AGENT ANTIMICROBIEN
  申请人：UNIV MARYLAND

  公开号：WO2008147445A2

  公开（公告）日：2008-12-04

  [EN] The invention relates to the areas of therapeutics, pharmaceuticals, drug discovery, and immunotherapy. More specifically, the present invention relates to methods of stimulating the immune system through the administration of flavone acetic acid [FAA] analogues, and in particular, the flavone acetic acid analogue, 5,6-dimethylxanthenone- 4-acetic acid (DMXAA) so as to comprise an antimicrobial therapeutic agent for the treatment of viral, fungal, bacterial or parasitic infections in humans and non-human animals. The invention is especially suitable for use in a process of treating and preventing infection by viruses (for example, rhinoviruses, enteroviruses, and influenza viruses, etc.) and bacteria (especially intracellular bacterial pathogens such as Francisella tularensis).
  [FR] La présente invention concerne les domaines thérapeutiques, pharmaceutiques, ainsi que ceux de la découverte de médicaments et de l'immunothérapie. L'invention porte plus spécifiquement sur les procédés de stimulation du système immunitaire par l'administration d'analogues d'acide flavone acétique [FAA] et, en particulier, l'analogue d'acide flavone acétique, l'acide 5,6-diméthylxanthénone- 4-acétique (DMXAA) afin d'obtenir un agent thérapeutique antimicrobien pour le traitement d'infections virales, fongiques, bactériennes ou parasitaires chez les animaux humains et non humains. L'invention est tout particulièrement adaptée au traitement et à la prévention des infections virales (par exemple, les rhinovirus, les entérovirus et les virus de la grippe, etc.) et bactériennes (notamment les pathogènes bactériens intracellulaires tels que la Francisella tularensis).