[2-(4-fluoro-2-methylphenoxy)ethyl]trimethylsilane | 1338215-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [2-(4-fluoro-2-methylphenoxy)ethyl]trimethylsilane
• 英文别名: 2-(4-Fluoro-2-methylphenoxy)ethyl-trimethylsilane；2-(4-fluoro-2-methylphenoxy)ethyl-trimethylsilane
• CAS: 1338215-44-3
• 化学式: C₁₂H₁₉FOSi
• 分子量: 226.366
• InChiKey: BATGBAHUEOUWNB-UHFFFAOYSA-N

物化性质

• 沸点：
  272.1±30.0 °C(Predicted)
• 密度：
  0.960±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.85
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [2-(4-fluoro-2-methylphenoxy)ethyl]trimethylsilane 在 cesium fluoride 、 水 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以79%的产率得到4-氟-2-甲基苯酚
  参考文献：
  名称：

  2-(Trimethylsilyl)ethanol as a new alcohol equivalent for copper-catalyzed coupling of aryl iodides

  摘要：

  2-(Trimethylsilyl)ethanol as a new alcohol equivalent has been employed for copper-catalyzed coupling of aryl iodides. Using mild reaction conditions, it has been observed that substituted phenols and phenols with sensitive functional groups can be readily prepared. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.023
• 作为产物：
  描述：

  2-(三甲硅基)乙醇 、 2-碘-5-氟甲苯 在 copper(l) iodide 、 1,10-菲罗啉 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 14.0h， 以92%的产率得到[2-(4-fluoro-2-methylphenoxy)ethyl]trimethylsilane
  参考文献：
  名称：

  2-(Trimethylsilyl)ethanol as a new alcohol equivalent for copper-catalyzed coupling of aryl iodides

  摘要：

  2-(Trimethylsilyl)ethanol as a new alcohol equivalent has been employed for copper-catalyzed coupling of aryl iodides. Using mild reaction conditions, it has been observed that substituted phenols and phenols with sensitive functional groups can be readily prepared. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.023

文献信息

• 2-(Trimethylsilyl)ethanol as a new alcohol equivalent for copper-catalyzed coupling of aryl iodides
  作者：Mullick Dibakar、Anjanappa Prakash、Kumaravel Selvakumar、Kandasamy Ruckmani、Manickam Sivakumar

  DOI：10.1016/j.tetlet.2011.08.023

  日期：2011.10

  2-(Trimethylsilyl)ethanol as a new alcohol equivalent has been employed for copper-catalyzed coupling of aryl iodides. Using mild reaction conditions, it has been observed that substituted phenols and phenols with sensitive functional groups can be readily prepared. (C) 2011 Elsevier Ltd. All rights reserved.