2',3'-dideoxy-4'-methyladenosine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2',3'-dideoxy-4'-methyladenosine
• 英文别名: [(2S,5R)-5-(6-aminopurin-9-yl)-2-methyl-tetrahydrofuran-2-yl]methanol；[(2S,5R)-5-(6-aminopurin-9-yl)-2-methyloxolan-2-yl]methanol
• 化学式: C₁₁H₁₅N₅O₂
• 分子量: 249.272
• InChiKey: VJLGZYHHLYREIH-HQJQHLMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  99.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  9-(4-C-methyl-β-D-ribofuranosyl)-adenine 在 钯 咪唑 、 1,3-二甲基-2-苯基-2-磷杂咪唑烷 、 四丁基氟化铵 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 10.84h， 生成 2',3'-dideoxy-4'-methyladenosine
  参考文献：
  名称：

  Synthesis and Biological Evaluation of 4′-C-Methyl Nucleosides

  摘要：

  A series of 2'-deoxy, 2',3'-unsaturated and 2',3'-dideoxynucleoside analogues, which have an additional methyl group at the 4'-position, have been synthesized. When evaluated for their inhibitory activity against HIV in MT-4 cell, 2'-deoxy-4'-C-methyl nucleosides exhibited potent activity.

  DOI：

  10.1080/07328319608002385

文献信息

• [EN] LINE-1 INHIBITORS AS COGNITIVE ENHANCERS<br/>[FR] INHIBITEURS DE LINE-1 UTILISÉS EN TANT QU'ACTIVATEURS COGNITIFS
  申请人：[en]TRANSPOSON THERAPEUTICS, INC.

  公开号：WO2022256625A1

  公开（公告）日：2022-12-08

  The present disclosure provides methods of enhancing cognition, inhibiting cognitive decline, treating or preventing a cognitive deficit disorder, or treating or preventing Creutzfeldt-Jakob disease (CJD) in a subject in need thereof comprising administering a LINE-1 inhibitor, or a pharmaceutical composition thereof, to the subject.
• Synthesis and Biological Evaluation of 4′-<i>C</i>-Methyl Nucleosides
  作者：Toshiaki Waga、Hiroshi Ohrui、Hiroshi Meguro

  DOI：10.1080/07328319608002385

  日期：1996.1

  A series of 2'-deoxy, 2',3'-unsaturated and 2',3'-dideoxynucleoside analogues, which have an additional methyl group at the 4'-position, have been synthesized. When evaluated for their inhibitory activity against HIV in MT-4 cell, 2'-deoxy-4'-C-methyl nucleosides exhibited potent activity.