(4S)-4-Ethyl-9-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-4-yl 2-aminoacetate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: (4S)-4-Ethyl-9-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-4-yl 2-aminoacetate
• 英文别名: [(19S)-19-ethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-19-yl] 2-aminoacetate
• 化学式: C₂₂H₁₉N₃O₆
• 分子量: 421.4
• InChiKey: WRUNRZWFHRZVFQ-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• MULTI-ARM POLYMERIC TARGETING ANTI-CANCER CONJUGATE
  申请人：Bright Gene Bio-Medical Technology Co., Ltd.

  公开号：EP3459546A1

  公开（公告）日：2019-03-27

  Disclosed is a multi-arm targeting drug conjugate modified by a water-soluble polymer; the drug conjugate has the structural formula of (III). In formula (III), R is an organic core, POLY is a polymer, L is a multivalent linker, T is a targeting molecule, D is a camptothecin-based drug, and q is any integer between 3 and 8. The drug conjugate may improve the poor water solubility, high toxicity and low bioavailability of camptothecin-based drugs.

  本发明公开了一种由水溶性聚合物修饰的多臂靶向药物共轭物；该药物共轭物的结构式为(III)。式（III）中，R 是有机核，POLY 是聚合物，L 是多价连接体，T 是靶向分子，D 是喜树碱类药物，q 是 3 到 8 之间的任意整数。该药物共轭物可改善喜树碱类药物水溶性差、毒性大和生物利用率低的问题。
• Multi-arm polymeric targeting anti-cancer conjugate
  申请人：BrightGene Bio-Medical Technology Co., Ltd.

  公开号：US10869863B2

  公开（公告）日：2020-12-22

  Disclosed is a multi-arm targeting drug conjugate modified by a water-soluble polymer; the drug conjugate has the structural formula of (III). In formula (III), R is an organic core, POLY is a polymer, L is a multivalent linker, T is a targeting molecule, D is a camptothecin-based drug, and q is any integer between 3 and 8. The drug conjugate may improve the poor water solubility, high toxicity and low bioavailability of camptothecin-based drugs.

  本发明公开了一种由水溶性聚合物修饰的多臂靶向药物共轭物；该药物共轭物的结构式为(III)。 式（III）中，R 是有机核，POLY 是聚合物，L 是多价连接体，T 是靶向分子，D 是喜树碱类药物，q 是 3 到 8 之间的任意整数。 该药物共轭物可改善喜树碱类药物水溶性差、毒性大和生物利用率低的问题。
• Polyglutamic acid-camptothecin conjugates and methods of preparation
  申请人：——

  公开号：US20020016285A1

  公开（公告）日：2002-02-07

  The invention provides polyglutamic acid-therapeutic agent conjugates and methods for their preparation and use.

  本发明提供了聚谷氨酸-治疗剂共轭物及其制备和使用方法。
• POLYGLUTAMIC ACID-CAMPTOTHECIN CONJUGATES AND METHODS OF PREPARATION
  申请人：CELL THERAPEUTICS, INC.

  公开号：EP1267939A2

  公开（公告）日：2003-01-02
• US7153864B2
  申请人：——

  公开号：US7153864B2

  公开（公告）日：2006-12-26