2-cyclohexyl-N-[2-(4-ethylphenyl)-1,3-benzoxazol-5-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-cyclohexyl-N-[2-(4-ethylphenyl)-1,3-benzoxazol-5-yl]acetamide
• 化学式: C₂₃H₂₆N₂O₂
• 分子量: 362.472
• InChiKey: PHFCTRYVAASSPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对乙基苯甲酸 在 碳酸氢钠 作用下， 以 乙醚 为溶剂， 反应 2.5h， 生成 2-cyclohexyl-N-[2-(4-ethylphenyl)-1,3-benzoxazol-5-yl]acetamide
  参考文献：
  名称：

  Synthesis and microbiological activity of some novel N-[2-(p-substitutedphenyl)-5-benzoxazolyl]-cyclohexyl carboxamide, -cyclohexyl acetamide and -cyclohexyl propionamide derivatives

  摘要：

  The synthesis and microbiological activity of a new series of N-[2-(p-substitutedphenyl)-5-benzoxazolyl]-cyclohexyl carboxamide, -cyclohexyl acetamide and -cyclohexyl propionamide derivatives (4-11) is described. The in vitro microbiological activity of the compounds was determined against gram-positive, gram-negative bacteria and the yeast Candida albicans in comparison with standard drugs. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms.

  DOI：

  10.1016/s0014-827x(02)01278-8

文献信息

• Synthesis and microbiological activity of some novel N-[2-(p-substitutedphenyl)-5-benzoxazolyl]-cyclohexyl carboxamide, -cyclohexyl acetamide and -cyclohexyl propionamide derivatives
  作者：Özlem Temiz Arpacı、Esin Akı Şener、İsmail Yalçın、Nurten Altanlar

  DOI：10.1016/s0014-827x(02)01278-8

  日期：2002.9

  The synthesis and microbiological activity of a new series of N-[2-(p-substitutedphenyl)-5-benzoxazolyl]-cyclohexyl carboxamide, -cyclohexyl acetamide and -cyclohexyl propionamide derivatives (4-11) is described. The in vitro microbiological activity of the compounds was determined against gram-positive, gram-negative bacteria and the yeast Candida albicans in comparison with standard drugs. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms.