3-(2-deoxy-β-D-ribofuranosyl)-4-methyl-2H-1,3-thiazolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(2-deoxy-β-D-ribofuranosyl)-4-methyl-2H-1,3-thiazolin-2-one
• 英文别名: 3-((4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-methyl-3H-thiazol-2-one；3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-methyl-1,3-thiazol-2-one
• 化学式: C₉H₁₃NO₄S
• 分子量: 231.273
• InChiKey: ANWBDEYHMPCJMI-XLPZGREQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  95.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 3-O-tert-butyldiphenylsilyl-2-deoxy-5-O-[4-methyl-1,3-thiazol-2-yl]-D-ribofuranoside 在 四丁基氟化铵 作用下， 以95%的产率得到3-(2-deoxy-β-D-ribofuranosyl)-4-methyl-2H-1,3-thiazolin-2-one
  参考文献：
  名称：

  SYNTHESIS OF THIAAZAHETEROCYCLE NUCLEOSIDE ANALOGUES

  摘要：

  The syntheses of thiazinone, thiazinedione and thiazolinone base modified nucleoside analogues have been discussed in both the deoxy- and ribosyl series. Both inter- and intramolecular N-glycosylations were evaluated.

  DOI：

  10.1081/ncn-120006829

文献信息

• SYNTHESIS OF THIAAZAHETEROCYCLE NUCLEOSIDE ANALOGUES
  作者：A. Ané、G. Prestat、M. Thiam、S. Josse、M. Pipelier、J. P. Pradère、D. Dubreuil

  DOI：10.1081/ncn-120006829

  日期：2002.7

  The syntheses of thiazinone, thiazinedione and thiazolinone base modified nucleoside analogues have been discussed in both the deoxy- and ribosyl series. Both inter- and intramolecular N-glycosylations were evaluated.