2-(N-Nicotinylamino)-5-carbethoxy-thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(N-Nicotinylamino)-5-carbethoxy-thiazole
• 英文别名: ethyl 2-(pyridin-3-ylmethylamino)-1,3-thiazole-5-carboxylate
• 化学式: C₁₂H₁₃N₃O₂S
• 分子量: 263.32
• InChiKey: CVQJWYMXXPYVLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] INHIBITION OF HAIR GROWTH<br/>[FR] INHIBITION DE LA CROISSANCE DES CHEVEUX
  申请人：UNIV MANCHESTER

  公开号：WO2016102969A1

  公开（公告）日：2016-06-30

  The invention relates to nicotinamide, or a precursor or derivative thereof, for use in the inhibition of hair growth. The invention also relates to methods of inhibiting hair growth by providing a subject with an effective amount of nicotinamide, or a precursor or derivative thereof. The uses and methods according to the invention, may be particularly useful in the inhibition of hair growth after hair removal by mechanical or chemical methods. The invention also relates to nicotinamide, or a precursor or derivative thereof, for use in the inhibition of hair growth, wherein the agent is for use in combination with a further active agent that does not inhibit hair growth, such as palmitoylethanolamide (PEA).