3-(2-amino-1H-imidazol-4-yl)propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(2-amino-1H-imidazol-4-yl)propanoic acid
• 英文别名: 3-(2-amino-1H-imidazol-5-yl)propanoic acid
• 化学式: C₆H₉N₃O₂
• 分子量: 155.15
• InChiKey: HJTNPVMMYKBUPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Inhibitors of cysteine proteases and methods of use thereof
  申请人：Pardes Biosciences, Inc.

  公开号：US11124497B1

  公开（公告）日：2021-09-21

  The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease. Exemplary compounds provided include Formula II-I, where R3, RB are provided herein:

  该披露提供了具有战斗头的化合物及其在治疗医学疾病或紊乱，如病毒感染方面的用途。提供了制药组合物和制备各种带有战斗头的化合物的方法。这些化合物被认为能够抑制蛋白酶，如3C、CL-或3CL样蛋白酶。提供的示例化合物包括Formula II-I，其中R3、RB如下所示：
• [EN] HISTIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USES<br/>[FR] DÉRIVÉS D'HISTIDINE ET LEURS UTILISATIONS PHARMACEUTIQUES
  申请人：AKD GLOBAL INC

  公开号：WO2010115130A1

  公开（公告）日：2010-10-07

  Disclosed herein are the compositions and methods for a compound of Formula Ia or Ib.

  本文披露了一种公式Ia或Ib的化合物的组成和方法。
• Soldering flux and solder paste composition
  申请人：Denso Corporation

  公开号：EP1897652A1

  公开（公告）日：2008-03-12

  A soldering flux contains a base resin and an activating agent. The soldering flux contains, as the activating agent, an oxygen-containing heterocyclic compound having at least one carboxyl group in a molecule. A solder paste composition contains the abovementioned soldering flux and the solder alloy powder. These enable exhibition of excellent wettability to lead-free metals and plating, irrespective of the type of the metals.

  一种焊接助焊剂含有一种基础树脂和一种活化剂。作为活化剂，助焊剂含有一种分子中至少含有一个羧基的含氧杂环化合物。焊膏组合物包含上述焊剂和焊料合金粉。无论金属的类型如何，它们都能对无铅金属和电镀产生极佳的润湿性。
• Waterborne adhesive
  申请人：Han Qiwen

  公开号：US20080146710A1

  公开（公告）日：2008-06-19

  Novel waterborne adhesives comprising a crosslinkable polymer, a crosslinking agent and acetaldehyde scavenger are useful in the manufacture of products exhibiting reduced acetaldehyde emission rates. Manufactured products having acetaldehyde emission rates of less than 9 μg/m 3 may be manufactured using the adhesive of the invention.
• INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
  申请人：Pardes Biosciences, Inc.

  公开号：US20210355111A1

  公开（公告）日：2021-11-18

  The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.