2,3-Diphenyl-5-(2-thienyl)tetrazolium Chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,3-Diphenyl-5-(2-thienyl)tetrazolium Chloride
• 英文别名: 2,3-diphenyl-5-thiophen-2-yltetrazol-2-ium;chloride
• 化学式: C17H13ClN4S
• 分子量: 340.8
• InChiKey: RLHVMOZOYHDIGV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.28
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Method of measuring substance in sample using a redox reaction
  申请人：Kyoto Daiichi Kagaku Co., Ltd.

  公开号：US20020025546A1

  公开（公告）日：2002-02-28

  A highly reliable method of measuring an analyte in a sample using a redox reaction. In this method, a tetrazolium compound is added to a sample prior to the redox reaction so as to eliminate the influence of any reducing substance in the sample, then a reducing substance or an oxidizing substance derived from the analyte is formed, the quantity of the formed substance derived from the analyte is measured by the redox reaction, and the quantity of the analyte is determined from the quantity of the formed substance derived from the analyte. As the tetrazolium compound, for example, 2-(4-iodophenyl)-3-(2,4-dinitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium salt can be used.

  一种高度可靠的测量样品中分析物的方法，使用氧化还原反应。在该方法中，在氧化还原反应之前向样品中添加四唑化合物以消除样品中任何还原物质的影响，然后形成从分析物中衍生的还原物质或氧化物质，通过氧化还原反应测量从分析物中衍生的物质的数量，并从中确定分析物的数量。例如，可以使用2-（4-碘苯基）-3-（2,4-二硝基苯基）-5-（2,4-二硫酚基）-2H-四唑盐作为四唑化合物。
• Redox reactions for analyte determination using tetrazolium compounds
  申请人：Kyoto Daiichi Kagaku Co., Ltd.

  公开号：EP1002874A2

  公开（公告）日：2000-05-24

  A highly reliable method of measuring an analyte in a sample using a redox reaction. In this method, a tetrazolium compound is added to a sample prior to the redox reaction so as to eliminate the influence of any reducing substance in the sample, then a reducing substance or an oxidizing substance derived from the analyte is formed, the quantity of the formed substance derived from the analyte is measured by the redox reaction, and the quantity of the analyte is determined from the quantity of the formed substance derived from the analyte. As the tetrazolium compound, for example, 2-(4-iodophenyl)-3-(2,4-dinitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium salt can be used.

  一种利用氧化还原反应测量样品中分析物的高度可靠的方法。在这种方法中，在氧化还原反应之前向样品中加入四唑化合物，以消除样品中任何还原性物质的影响，然后形成由被分析物衍生的还原性物质或氧化性物质，通过氧化还原反应测量由被分析物衍生的已形成物质的数量，并根据由被分析物衍生的已形成物质的数量确定被分析物的数量。例如，可以使用 2-(4-碘苯基)-3-(2,4-二硝基苯基)-5-(2,4-二磺酸苯基)-2H-四唑鎓盐作为四唑化合物。
• Dental composition
  申请人：3M Innovative Properties Company

  公开号：EP2052712A1

  公开（公告）日：2009-04-29

  The present invention relates to a bacteria detecting dental composition comprising a solution of at least one electron acceptor and at least one electron donor wherein the electron acceptor and the electron donor are selected that in the solution itself the electron donor can not transmit reduction equivalents to the electron acceptor and wherein the dental composition is substantially free of compounds that enable or facilitate the electron transmission between the electron acceptor and the electron donor. The present invention further relates to the use of a composition comprising a solution of at least one electron acceptor and at least one electron donor wherein the electron acceptor and the electron donor are selected that in the solution itself the electron donor can not transmit reduction equivalents to the electron acceptor and wherein the composition is substantially free of compounds that enable or facilitate the electron transmission between the electron acceptor and the electron donor for site-directed intraoral detection of bacteria.

  本发明涉及一种细菌检测牙科组合物，该组合物包含至少一种电子受体和至少一种电子供体的溶液，其中电子受体和电子供体被选择为在溶液本身中电子供体不能向电子受体传递还原当量，并且该牙科组合物基本上不含能够或促进电子受体和电子供体之间电子传递的化合物。 本发明进一步涉及一种由至少一种电子受体和至少一种电子供体的溶液组成的组合物的用途，其中电子受体和电子供体被选择为在溶液本身中电子供体不能向电子受体传递还原当量，并且该组合物基本上不含能够或促进电子受体和电子供体之间电子传递的化合物，用于口腔内定点细菌检测。
• Azithromycin derivatives with epithelial barrier enhancement properties
  申请人：EpiEndo Pharmaceuticals ehf

  公开号：US10723752B2

  公开（公告）日：2020-07-28

  The invention provides novel compounds that are derivatives of Azithromycin and that have been found by the current inventors to have low antimicrobial activity but significant epithelial barrier enhancement properties. The invention further provides use of the compounds as a medicament, in particular in the treatment or prophylaxis of a disease or condition that is caused by a defect in epithelial cells or tissue, or a disease or condition that benefits from enhancement or restoration of epithelial barrier function, for example diseases of the respiratory tract.

  本发明提供了新型化合物，它们是阿奇霉素的衍生物，本发明人发现它们具有较低的抗菌活性，但具有显著的上皮屏障增强特性。本发明进一步提供了这些化合物作为药物的用途，特别是用于治疗或预防由上皮细胞或组织缺陷引起的疾病或病症，或受益于上皮屏障功能增强或恢复的疾病或病症，例如呼吸道疾病。
• DENTAL COMPOSITION FOR DETECTING BACTERIA, KIT OF PARTS AND USE THEREOF
  申请人：3M Innovative Properties Company

  公开号：EP2200562A2

  公开（公告）日：2010-06-30

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