Benzimidazole, 1-(2-furoyl)-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: Benzimidazole, 1-(2-furoyl)-
• 英文别名: benzimidazol-1-yl(furan-2-yl)methanone
• 化学式: C₁₂H₈N₂O₂
• mdl: MFCD00588872
• 分子量: 212.208
• InChiKey: MKTOOJYQEIEQNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  糠酸（呋喃甲酸） 、 2-(N-Boc-amino)phenylisocyanide 以 1,2-二氯乙烷 为溶剂， 反应 0.33h， 以79%的产率得到Benzimidazole, 1-(2-furoyl)-
  参考文献：
  名称：

  Facile One-Pot Synthesis of Benzimidazole and Quinoxalin-2(1H)-one Scaffolds via Two-Component Coupling Reaction, Deprotection, and Intermolecular Cyclization

  摘要：

  Two scaffolds, namely benzimidazole and quinoxalin2(1H)-one, were synthesized by treating 2-(N-Boc-amino)phenylisocyanide (Boc: tert-butoxycarbonyl) with carboxylic acids and glyoxylic acids, respectively. The target compounds were generated directly after two-component coupling, deprotection, and intermolecular cyclization.

  DOI：

  10.1055/s-0034-1379016

文献信息

• Facile One-Pot Synthesis of Benzimidazole and Quinoxalin-2(1H)-one Scaffolds via Two-Component Coupling Reaction, Deprotection, and Intermolecular Cyclization
  作者：Jin Zhang、Zhi-Gang Xu、Zhong-Zhu Chen、Ying Tang、Lei Zuo、Dian-Yong Tang

  DOI：10.1055/s-0034-1379016

  日期：——

  Two scaffolds, namely benzimidazole and quinoxalin2(1H)-one, were synthesized by treating 2-(N-Boc-amino)phenylisocyanide (Boc: tert-butoxycarbonyl) with carboxylic acids and glyoxylic acids, respectively. The target compounds were generated directly after two-component coupling, deprotection, and intermolecular cyclization.