butenedioic acid disec-butyl ester | 2210-32-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: butenedioic acid disec-butyl ester
• 英文别名: Dibutan-2-yl but-2-enedioate
• CAS: 2210-32-4
• 化学式: C₁₂H₂₀O₄
• 分子量: 228.288
• InChiKey: MWJNGKOBSUBRNM-UHFFFAOYSA-N

物化性质

• 沸点：
  262°C (estimate)
• 密度：
  0.9750

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2917190090

反应信息

• 作为反应物：
  描述：

  四氢呋喃 、 butenedioic acid disec-butyl ester 在 苯甲酰甲酸 作用下， 以83%的产率得到
  参考文献：
  名称：

  苯乙醛酸：杂环光化学氢原子转移CH功能化的有效引发剂。

  摘要：

  杂环α-位处的CH功能化已成为一个快速发展的研究领域。在此，开发了一种便宜而有效的光化学方法，用于杂环的C H功能化。苯乙醛酸（PhCOCOOH）可以替代金属基催化剂和有机染料，并提供了非常广泛的光化学CH烷基化，烯基化和炔化以及CN键形成反应的方法。这种新颖，温和且不含金属的方案不仅利用O或N杂环，而且利用了研究较少的S杂环成功地用于各种CH键的官能化。

  DOI：

  10.1002/cssc.202001892

文献信息

• Compound having silsesquioxane skeleton and its polymer
  申请人：Inagaki Jyun-ichi

  公开号：US20050009982A1

  公开（公告）日：2005-01-13

  The present invention relates to a compound represented by Formula (1) and a polymer obtained using the compound: wherein R 1 is phenyl which may have substituents, Q 1 is hydrogen, halogen, alkyl having 1 to 10 carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl or phenyl in which optional hydrogen may be replaced by halogen or alkyl having 1 to 5 carbon atoms, and Q 2 is a group represented by Formula (2) wherein the code < represents a bonding point with silicon, l, m, n and p are independently 0, 1, 2 or 3, A 1 to A 4 are independently a single bond, 1,4-cyclohexylene, 1,4-cyclohexenylene, a condensed ring group having 6 to 10 carbon atoms which is a divalent group, or 1,4-phenylene, Z 0 to Z 3 are independently a single bond, —CH═CR—, —C≡C—, —COO—, —OCO—, or alkylene having 1 to 20 carbon atoms, and Z 4 is a single bond, —CH═CH—, —C≡C—, —COO—, —OCO—, or alkylene having 1 to 20 carbon atoms. And Y 1 in Formula (1) is the group defined in Claim 1.

  本发明涉及一种由式（1）表示的化合物和使用该化合物获得的聚合物：其中R1是苯基，可能具有取代基；Q1是氢、卤素、具有1至10个碳原子的烷基、环丙基、环丁基、环戊基、环己基、环己烯基或苯基，其中可选的氢原子可被卤素或具有1至5个碳原子的烷基取代；Q2是由式（2）表示的基团，其中代码<表示与硅的连接点，l、m、n和p独立地为0、1、2或3，A1至A4独立地为单键、1,4-环己亚基、1,4-环己烯亚基、具有6至10个碳原子的缩合环基团，为二价基团，或1,4-苯亚基，Z0至Z3独立地为单键、—CH═CR—、—C≡C—、—COO—、—OCO—或具有1至20个碳原子的烷基，Z4为单键、—CH═CH—、—C≡C—、—COO—、—OCO—或具有1至20个碳原子的烷基。式（1）中的Y1是权利要求1中定义的基团。
• Green Photo-Organocatalytic C−H Activation of Aldehydes: Selective Hydroacylation of Electron-Deficient Alkenes
  作者：Giorgos N. Papadopoulos、Errika Voutyritsa、Nikolaos Kaplaneris、Christoforos G. Kokotos

  DOI：10.1002/chem.201705634

  日期：2018.2.1

  Selective C−H activation is an area of growing importance. Metal‐free C−H activation of branched aldehydes mediating the hydroacylation of electron‐deficient alkenes is an attractive transformation, but is limited by selectivity issues, especially in the case of α,α‐disubstituted aldehydes. Herein, we report a green, cheap, versatile, and easily reproducible selective hydroacylation of alkenes utilizing

  选择性CH活化是一个日益重要的领域。介导电子缺陷烯烃加氢酰化的支链醛的无金属CH活化是有吸引力的转变，但受选择性问题的限制，尤其是在α，α-二取代醛的情况下。本文中，我们报道了一种绿色，廉价，通用且易于重现的烯烃选择性加氢酰化反应，该方法利用苯乙醛酸作为光催化剂和普通家用灯泡进行辐照，从而获得了具有出色收率和选择性的产品。还研究了反应机理以说明高选择性。
• Durable coating compositions containing novel aspartic amine compounds
  申请人：Lenges Peter Christian

  公开号：US20060155148A1

  公开（公告）日：2006-07-13

  A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula: wherein X, R 1 , R 2 , p, m and n are described in the specification, or isomer or mixture of isomers thereof, two component compositions, articles coated with the novel composition and novel hydroxy amines are also part of the invention.

  一种包括以下成分的涂层组合物：a. 聚异氰酸酯交联剂；b. 具有至少一种化合物的异氰酸酯反应组分，其具有以下公式：其中X、R1、R2、p、m和n在说明书中有描述，或其异构体或异构体混合物，还包括双组分组合物、涂有新型组合物的物品和新型羟胺在内。
• Bioadhesive polymers with catechol functionality
  申请人：Schestopol Marcus

  公开号：US20050201974A1

  公开（公告）日：2005-09-15

  Polymers with improved bioadhesive properties and methods for improving bioadhesion of polymers have been developed. A compound containing an aromatic group which contains one or more hydroxyl groups is grafted onto a polymer or coupled to individual monomers. In one embodiment, the polymer is a biodegradable polymer. In another embodiment, the monomers may be polymerized to form any type of polymer, including biodegradable and non-biodegradable polymers. In some embodiments, the polymer is a hydrophobic polymer. In the preferred embodiment, the aromatic compound is catechol or a derivative thereof and the polymer contains reactive functional groups. In the most preferred embodiment, the polymer is a polyanhydride and the aromatic compound is the catechol derivative, DOPA. These materials display bioadhesive properties superior to conventional bioadhesives used in therapeutic and diagnostic applications. These bioadhesive materials can be used to fabricate new drug delivery or diagnostic systems with increased residence time at tissue surfaces, and consequently increase the bioavailability of a drug or a diagnostic agent. In a preferred embodiment, the bioadhesive material is a coating on a controlled release oral dosage formulation and/or forms a matrix in an oral dosage formulation.

  开发了具有改善生物粘附性能的聚合物和改善聚合物生物粘附性的方法。一种含有芳香基且含有一个或多个羟基的化合物被嫁接到聚合物上或与单体耦合。在一种实施例中，聚合物是可生物降解的聚合物。在另一种实施例中，单体可以聚合形成任何类型的聚合物，包括可生物降解和不可生物降解的聚合物。在某些实施例中，聚合物是疏水性聚合物。在首选实施例中，芳香化合物是邻二酚或其衍生物，而聚合物含有反应性官能团。在最优选实施例中，聚合物是聚酸酐，而芳香化合物是邻二酚衍生物DOPA。这些材料表现出比用于治疗和诊断应用的传统生物粘附剂更优异的生物粘附性能。这些生物粘附材料可用于制造具有在组织表面增加停留时间并因此增加药物或诊断剂的生物利用度的新药物输送或诊断系统。在首选实施例中，生物粘附材料是受控释放口服剂型的涂层和/或口服剂型中的基质。
• Process for producing chromone compound
  申请人：Hibino Hiroaki

  公开号：US20050085664A1

  公开（公告）日：2005-04-21

  A process for producing a dicarboxylic acid compound represented by the formula (4): wherein R 1 and R 2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2): wherein R 1 , R 2 and the wavy line have the same meanings as the above, and one of X 2 and X 3 represents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3): in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5): wherein R 1 has the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.

  提供一种制备式（4）的二羧酸化合物的方法，其中R1和R2相同或不同，每个代表低级烷基，波浪线表示该化合物是E或Z异构体或它们的混合物，其特征在于将式（2）的化合物与硝基酚在碱的存在下反应，式中R1、R2和波浪线的含义与上述相同，X2和X3中的一个代表氢，另一个代表卤素；提供一种制备式（5）的硝基香豆素化合物的方法，其中R1的含义与上述相同，其特征在于将二羧酸化合物或其羧酸与酸反应；提供一种制备氨基香豆素化合物的方法，其包括还原硝基香豆素化合物；以及提供一种制备酰胺香豆素化合物的方法，其包括酰化氨基香豆素化合物。