(Z)-ethyl 9-cyanonon-5-enoate | 1314144-44-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-ethyl 9-cyanonon-5-enoate
• 英文别名: ethyl (Z)-9-cyanonon-5-enoate
• CAS: 1314144-44-9
• 化学式: C₁₂H₁₉NO₂
• 分子量: 209.288
• InChiKey: TUUVIJPXYRBMAF-ARJAWSKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (Z)-6-iodohex-5-enenitrile 、 γ-(Iodzinkio)buttersaeureethylester 在 bis-triphenylphosphine-palladium(II) chloride 、 四甲基乙二胺 作用下， 以 四氢呋喃 为溶剂， 以94%的产率得到(Z)-ethyl 9-cyanonon-5-enoate
  参考文献：
  名称：

  Ligand Effects on Negishi Couplings of Alkenyl Halides

  摘要：

  Negishi couplings at olefinic centers do not always occur with the anticipated maintenance of stereochemistry. The source of erosion has been traced to the ligand, and a modified method has been developed that solves the stereochemical issue and significantly improves yields of Negishi couplings in general.

  DOI：

  10.1021/ol2010165

文献信息

• Ligand Effects on Negishi Couplings of Alkenyl Halides
  作者：Arkady Krasovskiy、Bruce H. Lipshutz

  DOI：10.1021/ol2010165

  日期：2011.8.5

  Negishi couplings at olefinic centers do not always occur with the anticipated maintenance of stereochemistry. The source of erosion has been traced to the ligand, and a modified method has been developed that solves the stereochemical issue and significantly improves yields of Negishi couplings in general.