Nymphaeol A | 73676-38-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Nymphaeol A
• 英文别名: (2S)-2-(3,4-dihydroxyphenyl)-6-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-2,3-dihydrochromen-4-one
• CAS: 73676-38-7
• 化学式: C₂₅H₂₈O₆
• 分子量: 424.5
• InChiKey: XCYSQFHYFNWYFP-CEMXSPGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS<br/>[FR] PROCÉDÉS DE PRÉPARATION DE COMPOSÉS HYDROXY-ARYLE ORTHO-ALLYLÉS
  申请人：UNIV MCMASTER

  公开号：WO2021237371A1

  公开（公告）日：2021-12-02

  The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

  本申请描述了一种制备邻烯丙基羟基芳基化合物的方法，例如通过在非质子溶剂中，在氧化铝和铝烷氧化物中选择的铝化合物存在下，将烯丙醇与羟基芳基化合物反应，其中羟基芳基化合物中至少有一个碳原子位于羟基的邻位且未被取代。本申请还包括化合物的化学式（I）。
• COMPOUNDS FOR THE INHIBITION OF HISTONE DEACETYLASE
  申请人：Huang Chung-Yang

  公开号：US20090076130A1

  公开（公告）日：2009-03-19

  The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-neurodegenerative diseases and human spinal muscular atrophy (SMA).

  该发明涉及以下式(I)所表示的化合物，以及其药学上可接受的盐、立体异构体、对映异构体、前药和溶剂化物。该化合物可用作增强神经突起生长的药剂，并预防或治疗与HDAC相关的疾病，特别是肿瘤或细胞增殖性疾病。特别地，该发明的化合物可用作抗神经退行性疾病和人类脊髓肌肉萎缩症（SMA）的药剂。
• New use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly
  申请人：NatureWise Biotech & Medicals Corporation

  公开号：EP2277387A1

  公开（公告）日：2011-01-26

  The invention provides a method of changing a ratio of 68 to 64 kDa protein of MRJP3 in a royal jelly, a method of producing a royal jelly comprising MRJP3 having a changed ratio of 68 to 64 kDa protein relative to a control royal jelly and the royal jelly produced thereform. Also provided is a method of promoting the growth of the larva of a queen bee comprising feeding the larva of the queen bee a royal jelly of the invention. Further provided is a method of producing bee larva, pupa and queen bees with sizes larger than normal.

  本发明提供了一种改变蜂王浆中MRJP3的68与64 kDa蛋白比例的方法，一种生产含有MRJP3的蜂王浆的方法，相对于对照蜂王浆，MRJP3的68与64 kDa蛋白比例发生了改变，并以这种方法生产出蜂王浆。还提供了一种促进蜂王幼虫生长的方法，包括给蜂王幼虫喂食本发明的蜂王浆。此外，还提供了一种生产蜂王幼虫、蛹和蜂王的方法，其蜂王幼虫、蛹和蜂王的尺寸大于正常尺寸。
• Prenylflavanone compounds for modulating diabetes
  申请人：NatureWise Biotech & Medicals Corporation

  公开号：EP2783684A1

  公开（公告）日：2014-10-01

  The present invention is directed to a novel use of prenylflavanone compounds for control of blood glucose and treatment or prevention of diabetes.

  本发明涉及一种控制血糖和治疗或预防糖尿病的前黄烷酮化合物的新用途。
• Compounds for the inhibition of histone deacetylase
  申请人：NatureWise Biotech & Medicals Corporation

  公开号：EP2045247B1

  公开（公告）日：2015-04-08

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