N-(2-(3,4-dimethylphenyl)benzo[d]oxazol-5-yl)nicotinamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(2-(3,4-dimethylphenyl)benzo[d]oxazol-5-yl)nicotinamide
• 英文别名: N-[2-(3,4-dimethylphenyl)-1,3-benzoxazol-5-yl]pyridine-3-carboxamide
• 化学式: C₂₁H₁₇N₃O₂
• 分子量: 343.385
• InChiKey: GMVAPNWKQNTGTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME
  申请人：Industry-Academic Cooperation Foundation Yonsei University

  公开号：EP3431472A2

  公开（公告）日：2019-01-23

  The present invention relates to a novel compounds for inhibiting nicotinamide phosphoribosyltransferase (NamPT), a composition comprising the same, and various uses thereof.

  本发明涉及一种用于抑制烟酰胺磷酸核糖转移酶（NamPT）的新型化合物、包含该化合物的组合物及其各种用途。
• Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same
  申请人：CHECKMATE THERAPEUTICS INC.

  公开号：US11078195B2

  公开（公告）日：2021-08-03

  The present invention relates to a novel compounds for inhibiting nicotinamide phosphoribosyltransferase (NamPT), a composition comprising the same, and various uses thereof.

  本发明涉及一种用于抑制烟酰胺磷酸核糖转移酶（NamPT）的新型化合物、包含该化合物的组合物及其各种用途。
• [EN] NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME<br/>[FR] NOUVEAU COMPOSÉ POUR INHIBER LA NICOTINAMIDE PHOSPHORIBOSYLTRANSFÉRASE ET COMPOSITION CONTENANT LE NOUVEAU COMPOSÉ<br/>[KO] 니코틴아미드 포스포리보실트랜스퍼라제 억제용 신규 화합물 및 이를 포함하는 조성물
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIV

  公开号：WO2017160116A2

  公开（公告）日：2017-09-21

  본 발명은 니코틴아미드 포스포리보실트랜스퍼라제(Nicotinamide phosphoribosyltransferase, NamPT) 억제용 신규 화합물과 이를 포함하는 조성물 및 이의 다양한 용도에 관한 것이다.