N-methyl-glycyl=>glycyl=>glycyl=>glycine | 91307-66-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-methyl-glycyl=>glycyl=>glycyl=>glycine
• 英文别名: N-Methyl-glycyl=>glycyl=>glycyl=>glycin；N-Methylglycylglycylglycylglycine；2-[[2-[[2-[[2-(methylamino)acetyl]amino]acetyl]amino]acetyl]amino]acetic acid
• CAS: 91307-66-3
• 化学式: C₉H₁₆N₄O₅
• 分子量: 260.25
• InChiKey: JYYQHNFCOMQZDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.9
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  铜 、 N-methyl-glycyl=>glycyl=>glycyl=>glycine 以 水 为溶剂， 生成 、 、
  参考文献：
  名称：

  L-脯氨酸残基作为金属-肽系统协同作用的“断裂点”

  摘要：

  寡肽中的L-脯氨酸残基已显示出与铜（II）离子配位的“断裂点”，导致形成了大螯合物环，而肽则锁定在β构象中。

  DOI：

  10.1039/c39840000231
• 作为产物：
  描述：

  t-BuOCO-Sar-Gly-OCH2Ph2 在 palladium on activated charcoal 盐酸 、 氢气 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 为溶剂， 生成 N-methyl-glycyl=>glycyl=>glycyl=>glycine
  参考文献：
  名称：

  Pettit, Leslie D.; Steel, Ian; Formicka-Kozlowska, Grazyna, Journal of the Chemical Society, Dalton Transactions, 1985, p. 535 - 540

  摘要：

  DOI：

文献信息

• The effect of disorder on the chemical reactivity of an organic solid, tetraglycine methyl ester: Change of the reaction mechanism
  作者：Evgenyi Shalaev、Marina Shalaeva、George Zografi

  DOI：10.1002/jps.10066

  日期：2002.2

  Many drugs undergo chemical changes in the solid state, and understanding chemical reactivity of organic crystals is a critical factor in the drug development process. In this report, the impact of milling on the thermal chemical reactivity of an organic solid, tetraglycine methyl ester, was studied using DSC, isothermal calorimetry, chemical analysis (HPLC and insoluble residue determination), and

  许多药物在固态时都会发生化学变化，因此了解有机晶体的化学反应性是药物开发过程中的关键因素。在本报告中，使用DSC，等温量热法，化学分析（HPLC和不溶残留物测定）和粉末X射线衍射研究了研磨对有机固体四甘氨酸甲酯的热化学反应性的影响。经过非常短暂的铣削（5 s）后，检测到X射线衍射图和DSC曲线均发生了显着变化。这些变化被解释为无序相的形成。暂时将无序相鉴定为结合了结晶态（即长程有序）和非晶态（即玻璃化转变）状态的晶体中间相。在无序的物质中，
• PH-sensitive linkers for delivering a therapeutic agent
  申请人：GNT BIOTECH & MEDICALS CORPORATION

  公开号：US10688193B2

  公开（公告）日：2020-06-23

  The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.

  本发明提供了一种可同时结合金属纳米粒子和一种或多种不同分子大小的制剂的 pH 值敏感连接剂。本发明的连接剂可将药剂输送到涉及疾病过程的细胞或靠近细胞的地方，从而使药剂有选择地靶向作用于细胞。本发明的连接剂提供的靶向输送可用于疾病传感、成像、给药和治疗等。
• Sluyterman; Veenendaal, Recueil des Travaux Chimiques des Pays-Bas, 1952, vol. 71, p. 137,141,143,144,145
  作者：Sluyterman、Veenendaal

  DOI：——

  日期：——
• Single-phase and heterophase solid-state chemical kinetics of thermally induced methyl transfer in tetraglycine methyl ester
  作者：Evgenyi Yu Shalaev、Stephen R. Byrn、George Zografi

  DOI：10.1002/(sici)1097-4601(1997)29:5<339::aid-kin4>3.0.co;2-v

  日期：——

  To better understand the general interrelationships between chemical transformations and physical transformations in solid-state reactions, we have studied the kinetics of methyl transfer in polycrystalline samples of tetraglycine methyl ester (TGME) over the temperature range of 83 degrees C-115 degrees C. Changes in the concentrations of the reactant and various intermediates (sarcosyltriglycine methyl ester, METGME, and tetraglycine, TG) and products (sarcosyltriglycine, METG, and N,N-dimethyl glycyl triglycine, Me(2)TG) were measured over the entire time course of the reaction using HPLC. Corresponding measurements of physical transformations occurring during the course of the reaction were made using X-ray powder diffractometry and differential scanning calorimetry. Kinetic curves for the loss of TGME in the range of 83 degrees C-115 degrees C have a sigmoidal shape and collapse into one curve when plotted in terms of reduced time, t/t(0.5), as do plots of intermediate and product concentration plotted in the same manner. The first 25% of the reaction proceeds homogeneously through what is believed to be the formation of a crystalline solid solution of the intermediates and products in the reactant. The acceleratory character of the kinetic curves in the single-phase portion of the reaction has been described by a kinetic scheme that contains a concentration-dependent rate constant. The appearance of a new crystalline phase beyond 35% of the reaction changes the reaction mechanism from a bulk reaction to an interface-controlled process that causes further acceleration of the methyl transfer. The apparent activation energies for both single-phase and heterophase stages of the reaction are about 100-130 kJ/mole. (C) 1997 John Wiley & Sons, Inc.
• PH-SENSITIVE LINKERS FOR DELIVERING A THERAPEUTIC AGENT
  申请人：GNT BIOTECH & MEDICALS CORPORATION

  公开号：US20180221498A1

  公开（公告）日：2018-08-09

  The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.