4-ethyl-6-(5-methyl-4-phenoxy-1H-pyrazol-3-yl)-1,3-benzenediol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-ethyl-6-(5-methyl-4-phenoxy-1H-pyrazol-3-yl)-1,3-benzenediol
• 英文别名: 4-ethyl-6-(5-methyl-4-phenoxy-1H-pyrazol-3-yl)benzene-1,3-diol
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.3
• InChiKey: GJIUSEJNABINDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators
  申请人：Eggenweiler Hans-Michael

  公开号：US20080090880A1

  公开（公告）日：2008-04-17

  Novel phenylpyrazole derivatives of the formula (I), in which R 1 -R 6 , X and Y have the meanings indicated in Claim 1 , are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role

  式(I)的新型苯基吡唑衍生物，其中R1-R6，X和Y具有权利要求1中所示的含义，是HSP90抑制剂，并可用于制备用于治疗HSP90抑制，调节和/或调节在其中发挥作用的疾病的药物。
• COMPOUND OF RESORCINOL DERIVATIVE WITH POLYMER
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP2070971A1

  公开（公告）日：2009-06-17

  Provided is a high-molecular weight conjugate of resorcinol derivatives which is excellent in water solubility and stability and has high antitumor activity even when used in a smaller total drug amount than the resorcinol derivatives. The high-molecular weight conjugate of resorcinol derivatives comprises a structure in which a carboxyl group of polymer moiety having a carboxyl group in the side chain and polyethylene glycol moiety is linked to a hydroxyl group of resorcinol derivatives via an ester bond.

  本发明提供了一种间苯二酚衍生物的高分子量共轭物，它具有优异的水溶性和稳定性，即使使用的药物总量少于间苯二酚衍生物，也具有很高的抗肿瘤活性。间苯二酚衍生物的高分子量共轭物包括这样一种结构：侧链中含有羧基的聚合物分子和聚乙二醇分子的羧基通过酯键与间苯二酚衍生物的羟基相连。
• 3-(2-HYDROXYPHENYL)-PYRAZOLE UND IHRE VERWENDUNG ALS HSP90 MODULATOREN
  申请人：Merck Patent GmbH

  公开号：EP1799649B1

  公开（公告）日：2014-06-25
• High-molecular weight conjugate of resorcinol derivatives
  申请人：Nakamura Masaharu

  公开号：US20090239782A1

  公开（公告）日：2009-09-24

  Provided is a high-molecular weight conjugate of resorcinol derivatives which is excellent in water solubility and stability and has high antitumor activity even when used in a smaller total drug amount than the resorcinol derivatives. The high-molecular weight conjugate of resorcinol derivatives comprises a structure in which a carboxyl group of polymer moiety having a carboxyl group in the side chain and polyethylene glycol moiety is linked to a hydroxyl group of resorcinol derivatives via an ester bond.
• High-Molecular Weight Conjugate Of Resorcinol Derivatives
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：US20150011715A1

  公开（公告）日：2015-01-08

  Provided is a high-molecular weight conjugate of resorcinol derivatives which is excellent in water solubility and stability and has high antitumor activity even when used in a smaller total drug amount than the resorcinol derivatives. The high-molecular weight conjugate of resorcinol derivatives comprises a structure in which a carboxyl group of polymer moiety having a carboxyl group in the side chain and polyethylene glycol moiety is linked to a hydroxyl group of resorcinol derivatives via an ester bond.