5-乙酰氨基-2-氯苯酚 | 28443-52-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-乙酰氨基-2-氯苯酚
• 英文名称: N-(4-chloro-3-hydroxyphenyl)acetamide
• 英文别名: 5-Acetamino-2-chlor-phenol；2-chloro-5-acetylamino phenol；2-chloro-5-acetaminophenol；5-acetylamino-2-chlorophenol
• CAS: 28443-52-9
• 化学式: C₈H₈ClNO₂
• 分子量: 185.61
• InChiKey: FWPNOLFNLHAULD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2924299090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P330,P363,P501
• 危险性描述：
  H302,H312,H332
• 储存条件：
  存储条件：室温、密封、干燥

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: 5-Acetamido-2-chlorophenol
Synonyms: N-(4-Chloro-3-hydroxyphenyl)acetamide

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: 5-Acetamido-2-chlorophenol
CAS number: 28443-52-9

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C8H8ClNO2
Molecular weight: 185.6

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  5-乙酰氨基-2-氯苯酚 在 caesium carbonate 、 potassium hydroxide 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 3-(5-amino-2-chlorophenoxy)propan-1-ol
  参考文献：
  名称：

  7-(2-苯氧基乙氧基)-4(1H)-喹诺酮类的合成、抗疟活性及构效关系

  摘要：

  ICI 56,780 ( 5 ) 在啮齿动物疟疾模型中显示出因果预防和血液分裂活性（ED 50 = 0.05 mg/kg），但在感染伯氏疟原虫的小鼠中迅速获得了寄生虫学抗性。在此，我们描述了针对多药耐药恶性疟原虫的 EC 50低至 0.15 nM的5类似物的合成。通过在 7-(2-phenoxyethoxy)-4(1 H )-quinolone 核心的 3 位引入邻位取代的芳基部分，实现了对 atovaquone 的低交叉阻力指数 (RI) 的最佳活性。

  DOI：

  10.1021/jm200718m
• 作为产物：
  描述：

  2-氯-5-氨基苯酚 、 乙酸酐 在 溶剂黄146 作用下， 反应 0.08h， 以93%的产率得到5-乙酰氨基-2-氯苯酚
  参考文献：
  名称：

  7-(2-苯氧基乙氧基)-4(1H)-喹诺酮类的合成、抗疟活性及构效关系

  摘要：

  ICI 56,780 ( 5 ) 在啮齿动物疟疾模型中显示出因果预防和血液分裂活性（ED 50 = 0.05 mg/kg），但在感染伯氏疟原虫的小鼠中迅速获得了寄生虫学抗性。在此，我们描述了针对多药耐药恶性疟原虫的 EC 50低至 0.15 nM的5类似物的合成。通过在 7-(2-phenoxyethoxy)-4(1 H )-quinolone 核心的 3 位引入邻位取代的芳基部分，实现了对 atovaquone 的低交叉阻力指数 (RI) 的最佳活性。

  DOI：

  10.1021/jm200718m

文献信息

• 4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance
  申请人：Manetsch Roman

  公开号：US20130123258A1

  公开（公告）日：2013-05-16

  Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of a Plasmodium infection in the recipient subject, or to reduce the likelihood of the onset or establishment of a Plasmodium infection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.

  提供了4(1H)-喹啉酮衍生物，能有效抑制或消除疟原虫生命周期中至少一个阶段的生存能力，并且显示出减少目标寄生虫对化合物产生抗药性的倾向。具体来说，这些化合物可以是苯氧乙氧基喹啉酮的衍生物，包括但不限于7-(2-苯氧乙氧基)喹啉衍生物。这些化合物可以单独或与至少另一种衍生物化合物或其他抗疟疾化合物一起，向动物或人类受试者施用。治疗组合物可以配制成减少受试者体内疟原虫感染程度的程度，或者在寄生虫接触受试者之前施用，以减少疟原虫感染的可能性。治疗组合物可以配制成提供有效的单剂量抗疟疾化合物或多剂量，以在一段时间内施用。
• Oxidation dye for keratinic fibers containing 2-halo-5-acetaminophenol
  申请人：Societe Anonyme dite: L'Oreal

  公开号：US03948596A1

  公开（公告）日：1976-04-06

  A dye composition for keratinic fibers comprising in combination: A. at least one oxidation base selected from the group consisting of an aromatic or heterocyclic compound carrying either two amino groups or one amine group and one hydroxy group, fixed in para position relative to each other on the aromatic or heterocyclic nucleus of said compound, said oxidation base being in the form of a free base or in the form of an acid addition salt thereof; and B. at least one coupler of the formula: ##SPC1## Wherein X represents a member selected from the group consisting of F, Cl or Br.

  一种用于角蛋白纤维的染料组合物，包括以下组合部分：A. 至少一种氧化碱，所述氧化碱选自芳香族或杂环化合物群，该化合物携带两个氨基或一个胺基和一个羟基，固定在所述化合物的芳香族或杂环核上的对位位置，所述氧化碱以自由碱的形式或其酸盐形式存在；以及B. 至少一种符合以下公式的偶联剂：##SPC1## 其中X表示来自F、Cl或Br的成员。
• Nitrated coupler compounds useful in direct dyeing and simultaneous
  申请人：Societe Anonyme dite: L'Oreal

  公开号：US04473374A1

  公开（公告）日：1984-09-25

  A cosmetic composition for application to the hair contains either (a) at least one compound having the formula ##STR1## wherein R is hydrogen, alkyl or halogen; and R' is hydrogen, alkyl, hydroxyalkyl, carbamylalkyl, mesylaminoalkyl, aminoalkyl, acylaminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, piperidinoalkyl, morpholinoalkyl, carbamoyl, acyl or carbalkoxy; or (b) at least one of said compounds having formula I above and at least one benzene or heterocyclic oxidation base. The invention also relates to new couplers of formula I as well as to new indo compounds which result from the coupling of said compounds with an oxidation base. These cosmetic compositions for application to the hair are useful in direct dyeing, oxidation dyeing or simultaneous oxidation and direct dyeing or said hair.

  一种用于涂抹于头发的化妆品组合物包含以下任一成分：(a)至少一种具有以下式子的化合物##STR1##其中R为氢、烷基或卤素；R'为氢、烷基、羟基烷基、氨基甲酰基烷基、甲磺酰氨基烷基、氨基烷基、酰胺基烷基、单烷基氨基烷基、双烷基氨基烷基、哌啶基烷基、吗啉基烷基、氨甲酰基、酰基或羰基氧基；或(b)至少一种具有上述式I的化合物和至少一种苯或杂环氧化基。本发明还涉及式I的新偶联剂以及由上述化合物与氧化基偶联而成的新的吲哚化合物。这些用于涂抹于头发的化妆品组合物在直接染色、氧化染色或同时氧化和直接染色或头发中非常有用。
• Color light-sensitive materials with azo dyes
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04741997A1

  公开（公告）日：1988-05-03

  A color light-sensitive material is provided, having at least one image forming compound of the following formula (I) on a support (Dye--X).sub.q --Y (I) wherein Dye represents a magenta dye residue or a dye precursor residue represented by the following formula (II); X represents a bond or a binding group; Y represents a group capable of yielding a difference in diffusibility of a dye component before and after the reaction with a photographic silver salt imagewise having a latent image, corresponding to or reversely corresponding to said photographic silver salt; q is 1 or 2, and when q is 2, Dye-X may be the same or different; ##STR1## wherein the symbols are defined in the specification and claims.

  提供一种彩色感光材料，其在支撑体上具有至少一种以下式(I)的图像形成化合物（染料-X）.sub.q-Y，其中Dye代表品红染料残基或以下式(II)所代表的染料前体残基；X代表键合或结合基团；Y代表能够在与具有潜在图像的照相银盐反应前后产生染料组分扩散性差异的基团，该图像与或反向对应于所述照相银盐；q为1或2，当q为2时，Dye-X可以相同或不同；##STR1##其中符号在说明书和权利要求中定义。
• 4(1H)-quinolones having antimalarial activity with reduced chemical resistance
  申请人：Manetsch Roman

  公开号：US08877752B2

  公开（公告）日：2014-11-04

  Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of a Plasmodium infection in the recipient subject, or to reduce the likelihood of the onset or establishment of a Plasmodium infection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.

  提供了4(1H)-喹啉衍生物，它们有效地抑制或消除疟原虫生命周期中至少一个阶段的活力，并显示出减少诱导目标疟原虫对化合物的抗性的倾向。特别地，这些化合物可以是苯氧乙氧基喹啉衍生物，包括但不限于7-(2-苯氧乙氧基)喹啉衍生物。这些化合物可以单独或与至少一种其他衍生物化合物或其他抗疟疾化合物一起，用于动物或人类受试者。治疗组合物可以被配制成减少受试者中恶性疟原虫感染程度或在疟原虫接触受试者之前使用以减少恶性疟原虫感染的发生或建立可能性的有效单剂量抗疟疾化合物或多剂量抗疟疾化合物。