(R)-(-)-9-hydroxydecenoic acid | 83944-97-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (R)-(-)-9-hydroxydecenoic acid
• 英文别名: (R,E)-9-hydroxy-2-decenoic acid；(9R,2E)-9-hydroxydecenoic acid；(E,R)-(-)-9-Hydroxy-2-decensaeure；(2E,9R)-9-hydroxy-2-decenoic acid；(E,9R)-9-hydroxydec-2-enoic acid
• CAS: 83944-97-2
• 化学式: C₁₀H₁₈O₃
• 分子量: 186.251
• InChiKey: DZBLNYYGAKHAOJ-BNICOGTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Methyl 6-(2-methyl-1,3-dioxolan-2-yl)hexanoate 在 sodium hydroxide 、 sodium hydride 、 二异丁基氢化铝 作用下， 以 甲醇 、 甲苯 、 苯 为溶剂， 生成 (R)-(-)-9-hydroxydecenoic acid
  参考文献：
  名称：

  A microbial synthesis of R and S-9-hydroxy-(E)-2-decenoic acid(9-HDA), a queen honeybee pheromone

  摘要：

  (R,E)-9-hydroxy-2-decenoic acid (9-HDA) and its (S.E)- isomer have been prepared by using an organic-microbial approach.

  DOI：

  10.1016/s0957-4166(00)86050-4

文献信息

• Novel Carboxylic Acid and Antidepressant Composition Containing the Same as Active Ingredient
  申请人：Yoshimura Hiroyuki

  公开号：US20100184860A1

  公开（公告）日：2010-07-22

  The present invention provides a novel compound and antidepressant composition that can be effectively used for improving depressed mood and depressed state, particularly for depressed mood and depressed state in menopausal women. The compound of the present invention is represented by the following formula (1): wherein R 1 and R 2 are identical or different and represent a hydrogen atom, a hydroxyl group or an acetyloxy group, and n is an integer of 2 to 7, or a pharmaceutically acceptable salt or ester thereof. This compound is used as an active ingredient in the antidepressant composition. Examples of the compound of the invention include (2E)-9,10-dihydroxy-2-decenoic acid, (2Z)-9,10-dihydroxy-2-decenoic acid, (2E)-9-hydroxy-2-decenoic acid, and (2E)-7-acetoxy-2-heptenoic acid.

  本发明提供了一种新型化合物和抗抑郁剂组合物，可有效用于改善抑郁情绪和抑郁状态，特别是用于绝经期妇女的抑郁情绪和抑郁状态。本发明的化合物由以下式（1）表示：其中R1和R2相同或不同，代表氢原子、羟基或乙酰氧基，n为2至7的整数，或其药学上可接受的盐或酯。该化合物作为抗抑郁剂组合物中的活性成分使用。本发明的化合物示例包括（2E）-9,10-二羟基-2-癸烯酸，（2Z）-9,10-二羟基-2-癸烯酸，（2E）-9-羟基-2-癸烯酸和（2E）-7-乙酰氧基-2-庚烯酸。
• MUCOSAL IMMUNOMODULATOR
  申请人：Yamada Bee Company, Inc.

  公开号：EP3530270A1

  公开（公告）日：2019-08-28

  The present invention provides a mucosal immunomodulator comprising, as an active ingredient, at least one selected from the group consisting of compounds represented by the following formula (1), compounds represented by the following formula (2) and compounds represented by the following formula (3), and salts thereof.

  本发明提供了一种粘膜免疫调节剂，其活性成分包括至少一种选自下式（1）所代表的化合物、下式（2）所代表的化合物和下式（3）所代表的化合物及其盐类组成的组。
• Mucosal immunomodulator
  申请人：Yamada Bee Company, Inc.

  公开号：US11089805B2

  公开（公告）日：2021-08-17

  The present invention provides a mucosal immunomodulator comprising, as an active ingredient, at least one selected from the group consisting of compounds represented by the following formula (1), compounds represented by the following formula (2) and compounds represented by the following formula (3), and salts thereof.

  本发明提供了一种粘膜免疫调节剂，其活性成分包括至少一种选自下式（1）所代表的化合物、下式（2）所代表的化合物和下式（3）所代表的化合物及其盐类组成的组。
• Composition, method, and apparatus to attract bees
  申请人：——

  公开号：US20030147933A1

  公开（公告）日：2003-08-07

  Applicant's invention includes an improved bee attracting composition. Applicant's invention further includes a bee attracting device formed from his improved bee attracting composition. Applicant's bee attracting device can be further coated with a second bee attracting composition. Applicant's invention further includes a method and apparatus for attracting and immobilizing bees using a substrate coated with an adhesive composition upon which Applicant's bee attracting composition is disposed.

  申请人的发明包括一种改进的引蜂组合物。申请人的发明还包括一个由其改进的引蜂组合物形成的引蜂装置。申请人的引蜂装置可以进一步涂上第二种引蜂组合物。申请人的发明还包括一种使用涂有粘合剂组合物的基底吸引和固定蜜蜂的方法和装置，在该基底上放置了申请人的引蜂组合物。
• Enzyme reactions in apolar solvents. The resolution of branched and unbranched 2-alkanols by porcine pancreatic lipase.
  作者：Brian Morgani、Allan C. Oehlschlager、Thomas M. Stokes

  DOI：10.1016/s0040-4020(01)96905-4

  日期：1991.1

  Straight-chain and branched 2-alkanols were subjected to enzyme catalyzed transesterification in organic solvent using porcine pancreatic lipase, high enantioselectivity being generally observed. The method was applied to the synthesis of (R)-(-)-9-hydroxy-(E)-decenoic acid, a component of the queen bee mandibular gland pheromone.