N'-(3,3-dimethyl-3,4-dihydro-1-isoquinolinyl)-2-pyridinecarbohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢异喹啉
• 英文名称: N'-(3,3-dimethyl-3,4-dihydro-1-isoquinolinyl)-2-pyridinecarbohydrazide
• 英文别名: N'-(3,3-dimethyl-4H-isoquinolin-1-yl)pyridine-2-carbohydrazide
• 化学式: C₁₇H₁₈N₄O
• 分子量: 294.35
• InChiKey: FYDXTSDJPHQUMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHOD FOR THE PRODUCTION OF CELL LINES WITH LATENT IMMUNODEFICIENCY VIRUS
  申请人：The J. David Gladstone Institutes

  公开号：EP1463822B1

  公开（公告）日：2011-10-26
• CELL LINES WITH LATENT IMMUNODEFICIENCY VIRUS AND METHODS OF USE THEREOF
  申请人：VERDIN Eric

  公开号：US20080038716A1

  公开（公告）日：2008-02-14

  The present invention provides isolated cells that comprise, integrated into the genome of the cell, a transcription-competent immunodeficiency virus or a transcription-competent immunodeficiency virus-based retroviral vector. Under basal in vitro culture conditions, the immunodeficiency virus is latent, and the expression of the latent immunodeficiency virus can be reactivated. The invention farther provides methods of making a subject cell. The invention further provides screening methods for identifying agents that activate a latent immunodeficiency virus; and screening method for identifying agents that block reactivation of latent immunodeficiency virus expression in response to T cell activation signals. The invention further provides agents identified in the subject screening assays. The invention further provides methods of treating an immunodeficiency virus infection.
• US7232685B2
  申请人：——

  公开号：US7232685B2

  公开（公告）日：2007-06-19
• US7544467B2
  申请人：——

  公开号：US7544467B2

  公开（公告）日：2009-06-09