6-Methyl-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-Methyl-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole
• 化学式: C16H11N3O2S
• 分子量: 309.3
• InChiKey: DFBBAJAODRNWDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  91.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] IMAGING AGENTS USEFUL FOR IDENTIFYING AD PATHOLOGY<br/>[FR] AGENTS D'IMAGERIE UTILES POUR IDENTIFIER UNE PATHOLOGIE
  申请人：SIEMENS MEDICAL SOLUTIONS

  公开号：WO2010011964A2

  公开（公告）日：2010-01-28

  Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders.. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.