1-(4-amino-1,2,5-oxadiazol-3-yl)-5-(naphthalen-1-yl)-1H-1,2,3-triazole-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-(naphthalen-1-yl)-1H-1,2,3-triazole-4-carboxylic acid
• 英文别名: 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-naphthalen-1-yltriazole-4-carboxylic acid
• 化学式: C₁₅H₁₀N₆O₃
• mdl: MFCD04150012
• 分子量: 322.28
• InChiKey: QDBYDVBENWOGEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• INHIBITORS OF RSV REPLICATION AND APPLICATIONS THEREOF
  申请人：GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

  公开号：US20210244740A1

  公开（公告）日：2021-08-12

  Disclosed herein are compounds having antiviral activity, and, in particular, an inhibitory activity on the replication of Respiratory Syncytial Virus (RSV). Druggable target sites, including Px, in the RSV N protein are disclosed, as well as compounds targeting Px. The compounds can be used to treat patients with RSV infection.