5-(2-Chloro-4-methylphenyl)-3-(4-methylphenyl)-1,2,4-oxadiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(2-Chloro-4-methylphenyl)-3-(4-methylphenyl)-1,2,4-oxadiazole
• 化学式: C₁₆H₁₃ClN₂O
• 分子量: 284.74
• InChiKey: SCPCQDBRSAKIFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION
  申请人：Edge Albert

  公开号：US20120328580A1

  公开（公告）日：2012-12-27

  This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.
• US8859597B2
  申请人：——

  公开号：US8859597B2

  公开（公告）日：2014-10-14