4-methoxy-N-(4-methoxyphenethyl)benzenesulfonamide | 349139-48-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxy-N-(4-methoxyphenethyl)benzenesulfonamide
• 英文别名: N-(4-Methoxyphenyl)ethyl 4-methoxybenzenesulfonamide；4-methoxy-N-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide
• CAS: 349139-48-6
• 化学式: C₁₆H₁₉NO₄S
• mdl: MFCD01345686
• 分子量: 321.397
• InChiKey: OBJJVDWZGCVDCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  73
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-methoxy-N-(4-methoxyphenethyl)benzenesulfonamide 、 溴乙酸乙酯 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 以1.76 g (93%)的产率得到Ethyl N-(4-Methoxyphenyl)ethyl-N-4-methoxy-benzene Sulfonyl-glycinate
  参考文献：
  名称：

  N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of c-proteinase and for treating or preventing disorders related to unregulated collagen production

  摘要：

  本发明涉及一类新型有机分子，能够抑制C蛋白酶，并且利用它们来调节、调控和/或抑制异常胶原形成，作为治疗纤维化疾病的治疗方法。

  公开号：

  US06506936B1
• 作为产物：
  描述：

  对甲氧基苯磺酰氯 在 sodium azide 、 二氢吡啶 、 1,3-dicyano-5-fluoro-2,4,6-tris(diphenylamino)benzene 、 4-甲苯硫酚 作用下， 以 水 、 1,2-二氯乙烷 、 丙酮 为溶剂， 反应 10.0h， 生成 4-methoxy-N-(4-methoxyphenethyl)benzenesulfonamide
  参考文献：
  名称：

  Organo‐Photocatalytic Anti‐Markovnikov Hydroamidation of Alkenes with Sulfonyl Azides: A Combined Experimental and Computational Study

  摘要：

  The construction of C(sp3)−N bonds via direct N‐centered radical addition with olefins under benign conditions is a desirable but challenging strategy. Herein, we describe an organo‐photocatalytic approach to achieve anti‐Markovnikov alkene hydroamidation with sulfonyl azides in a highly efficient manner under transition‐metal‐free and mild conditions. A broad range of substrates, including both activated and unactivated alkenes, are suitable for this protocol, providing a convenient and practical method to construct sulfonylamide derivatives. A synergistic experimental and computational mechanistic study suggests that the additive, Hantzsch ester (HE), might undergo a triplet‐triplet energy transfer manner to achieve photosensitization by the organo‐photocatalyst under visible light irradiation. Next, the resulted triplet excited state 3HE* could lead to a homolytic cleavage of C4−H bond, which triggers a straightforward H‐atom transfer (HAT) style in converting sulfonyl azide to the corresponding key amidyl radical. Subsequently, radical addition of the amidyl radical to alkenes followed by HAT from p‐toluenethiol could proceed to afford the desired anti‐Markovnikov hydroamidation product. It is worth noting that mechanistic pathway bifurcation could be possible for this reaction. A feasible radical chain propagation mechanistic pathway is also proposed to rationalize the high efficiency of this reaction.

  DOI：

  10.1002/anie.202406069

文献信息

• N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of C-proteinase and for treating or preventing disorders related to unregulated collagen production
  申请人：——

  公开号：US20030191309A1

  公开（公告）日：2003-10-09

  The present invention relates to a novel class of organic molecules capable of inhibiting C-proteinase, and to their use to regulate, modulate and/or inhibit abnormal collagen formation as a therapeutic approach towards the treatment of fibrotic disorders.

  本发明涉及一种新型有机分子类，能够抑制C-蛋白酶，并且利用它们来调节、调节和/或抑制异常胶原形成，作为治疗纤维化疾病的治疗方法。
• SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES
  申请人：TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20150266819A1

  公开（公告）日：2015-09-24

  Compounds according to Formula I are provided: and salts thereof, wherein Q 1 , Q 2 , R 3 , R 4 , X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I). Q 2 -X—Y—CHR 3 —CHR 4 -Q 1 (I)

  提供符合公式I的化合物和其盐，其中Q1、Q2、R3、R4、X和Y的定义如本文所述。还提供了制备公式I化合物的方法，以及使用公式（I）化合物治疗细胞增殖性疾病（如癌症）的方法。Q2-X—Y—CHR3—CHR4-Q1（I）
• Substituted alkyl diaryl derivatives, methods of preparation and uses
  申请人：TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US10207989B2

  公开（公告）日：2019-02-19

  Compounds according to Formula I are provided: and salts thereof, wherein Q1, Q2, R3, R4, X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I). Q2-X—Y—CHR3—CHR4-Q1  (I)

  提供了根据式 I 的化合物：及其盐类，其中 Q1、Q2、R3、R4、X 和 Y 如本文所定义。还提供了制备式 I 化合物的方法，以及使用式 (I) 化合物治疗细胞增殖性疾病（如癌症）的方法。 Q2-X-Y-CHR3-CHR4-Q1 (I)
• [EN] SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES<br/>[FR] DÉRIVÉS ALKYL DIARYLES SUBSTITUÉS, PROCÉDÉS DE PRÉPARATION ET D'UTILISATIONS
  申请人：UNIV TEMPLE

  公开号：WO2014047110A3

  公开（公告）日：2014-06-26
• US6506936B1
  申请人：——

  公开号：US6506936B1

  公开（公告）日：2003-01-14