5-[(Furan-2-yl)methoxy]-5-oxopentanoic acid | 5116-49-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-[(Furan-2-yl)methoxy]-5-oxopentanoic acid
• 英文别名: 5-(furan-2-ylmethoxy)-5-oxopentanoic acid
• CAS: 5116-49-4
• 化学式: C₁₀H₁₂O₅
• 分子量: 212.202
• InChiKey: OAXMGUBECMCTSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  76.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  反-4-羟基-β-硝基苯乙烯 、 5-[(Furan-2-yl)methoxy]-5-oxopentanoic acid 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 生成 Pentanedioic acid furan-2-ylmethyl ester 4-((E)-2-nitro-vinyl)-phenyl ester
  参考文献：
  名称：

  Inhibition of the her2 tyrosine kinase and characterization of a hydrophobic site near the nucleotide binding domain

  摘要：

  A series of compounds was prepared to investigate the hydrophobic character of the HER2 receptor tyrosine kinase active site. These bisubstrate analogs contained hydrophobic moieties in place of the polar triphosphate and nucleoside fragments of the natural ATP ligand. Despite these modifications, good affinity was observed as measured by inhibition of receptor autophosphorylation. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00369-7
• 作为产物：
  描述：

  糠醇 、 戊二酸酐 在 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.25h， 生成 5-[(Furan-2-yl)methoxy]-5-oxopentanoic acid
  参考文献：
  名称：

  Inhibition of the her2 tyrosine kinase and characterization of a hydrophobic site near the nucleotide binding domain

  摘要：

  A series of compounds was prepared to investigate the hydrophobic character of the HER2 receptor tyrosine kinase active site. These bisubstrate analogs contained hydrophobic moieties in place of the polar triphosphate and nucleoside fragments of the natural ATP ligand. Despite these modifications, good affinity was observed as measured by inhibition of receptor autophosphorylation. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00369-7

文献信息

• OPTIMISED PREPARATIONS OF HIGHLY ADAPTABLE AGGREGATES
  申请人：Cevc, Gregor

  公开号：EP2688554A2

  公开（公告）日：2014-01-29
• US4478962A
  申请人：——

  公开号：US4478962A

  公开（公告）日：1984-10-23
• [EN] OPTIMISED PREPARATIONS OF HIGHLY ADAPTABLE AGGREGATES<br/>[FR] PRÉPARATIONS OPTIMISÉES D'AGRÉGATS À HAUT POUVOIR D'ADAPTATION
  申请人：CEVC GREGOR

  公开号：WO2012126966A2

  公开（公告）日：2012-09-27

  The present invention describes improved compositions comprising aggregates having a higher adaptability, or deformability, owing to the inclusion of certain hydrophilic additives, including suitable organic ionic compounds. The disclosed compositions demonstrate superior adaptability and stability over otherwise similar compositions lacking the disclosed additives. The invention furthermore provides methods for manufacturing said aggregate preparations, wherein the resulting preparations are useful for applications such as receiving an aggregate payload with active ingredients, for biological agent delivery, and for a non¬ invasive targeted treatment of localised body regions at or below the application site of said aggregates.
• Inhibition of the her2 tyrosine kinase and characterization of a hydrophobic site near the nucleotide binding domain
  作者：Joseph A. Maddry、Conrad Kussner、Jackie W. Truss、Shri Niwas、E. Lucile White、Cecil D. Kwong

  DOI：10.1016/s0960-894x(97)00369-7

  日期：1997.8

  A series of compounds was prepared to investigate the hydrophobic character of the HER2 receptor tyrosine kinase active site. These bisubstrate analogs contained hydrophobic moieties in place of the polar triphosphate and nucleoside fragments of the natural ATP ligand. Despite these modifications, good affinity was observed as measured by inhibition of receptor autophosphorylation. (C) 1997 Elsevier Science Ltd.