2-(1H-indol-3-yl)-2-phenylacetic acid | 50776-23-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(1H-indol-3-yl)-2-phenylacetic acid
• 英文别名: 3-Indolylphenylessigsaeure；indol-3-yl-phenyl-acetic acid；Indol-3-ylphenylacetic acid
• CAS: 50776-23-3
• 化学式: C₁₆H₁₃NO₂
• 分子量: 251.285
• InChiKey: IKPQWSVHKWSJDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氯-1-(1H-吲哚-3-基)-2-苯乙酮 以18%的产率得到
  参考文献：
  名称：

  BERGMAN J.; BAECKVALL J. E., TETRAHEDRON , 1975, 31, NO 17, 2063-2073

  摘要：

  DOI：

文献信息

• SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF
  申请人：Kolkhof Peter

  公开号：US20100105744A1

  公开（公告）日：2010-04-29

  The present application relates to novel 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindole derivatives, processes for the preparation thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases, and the use thereof for the manufacture of medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

  本申请涉及新颖的7-硫代甲基、7-亚砜基甲基和7-磺酰基甲基吲哚衍生物，其制备方法，单独或组合使用以治疗和/或预防疾病，以及用于制造用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• 3-Cyanoalkyl- and 3-hydroxyalkylindoles and use thereof
  申请人：Thede Kai

  公开号：US20110183928A1

  公开（公告）日：2011-07-28

  The present application relates to novel 3-cyanoalkyl- and 3-hydroxyalkyl-substituted indole derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.

  本申请涉及新型3-氰基烷基和3-羟基烷基取代的吲哚衍生物，其制备方法，单独或组合使用用于治疗和/或预防疾病，以及用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• Metal-Free Blue-Light-Mediated Cyclopropanation of Indoles by Aryl(diazo)acetates
  作者：Jun-Long Niu、Mao-Ping Song、Xing Zhang、Cong Du、He Zhang、Xiao-Cai Li、Yun-Long Wang

  DOI：10.1055/s-0037-1610668

  日期：2019.2

  Blue-light-mediated cyclopropanation of indoles with aryl(diazo)acetates has been developed. The salient features of this strategy are that it is metal-free, operationally simple and atom-efficient, and that it uses an environmentally friendly energy source. In this protocol, blue light was employed as the sole energy source for the transformation. A variety of cyclopropane-fused indoline compounds was obtained in moderate to excellent yields and high diastereoselectivities under mild conditions.

  通过芳基（重氮）乙酸酯的蓝光介导下，已经开发出吲哚的环丙烷化反应。该策略的显著特点是无金属，操作简单，原子效率高，并且使用环境友好的能源。在该方案中，蓝光被用作转化的唯一能源。在温和条件下，得到了多种环丙烷融合吲哚化合物，并获得了中等到优异的收率和高的对映选择性。
• SUBSTITUTED 7-SULFANYLMETHYL, 7-SULFINYLMETHYL AND 7-SULFONYLMETHYL INDOLES AND USE THEREOF
  申请人：Kolkhoe Peter

  公开号：US20110201564A1

  公开（公告）日：2011-08-18

  The present application relates to novel 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindole derivatives, processes for the preparation thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases, and the use thereof for the manufacture of medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

  本发明涉及一种新型的7-硫基甲基，7-亚磺酰基甲基和7-磺酰基甲基吲哚衍生物，其制备方法，其单独或与其他物质结合的用于治疗和/或预防疾病的用途，以及其用于制造用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病的药物。
• US8063234B2
  申请人：——

  公开号：US8063234B2

  公开（公告）日：2011-11-22