Trimethylgermyl-essigsaeure | 88512-87-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Trimethylgermyl-essigsaeure
• 英文别名: (Trimethylgermyl)-acetic acid；2-trimethylgermylacetic acid
• CAS: 88512-87-2
• 化学式: C₅H₁₂GeO₂
• 分子量: 176.739
• InChiKey: GAGCCMYPQJTCDV-UHFFFAOYSA-N

物化性质

• 熔点：
  43.5 °C
• 沸点：
  197.7±42.0 °C(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.41
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  溴甲苯 、 Trimethylgermyl-essigsaeure 在 LDA 作用下， 以 四氢呋喃 为溶剂， 以80%的产率得到2-(trimethylgermyl)-3-phenylpropanoic acid
  参考文献：
  名称：

  Synthesis of α-germyl and α-silylcarboxylic acids and selected electrochemical oxidations

  摘要：

  New alpha-germylcarboxylic acids, alpha-silyl-alpha-halocarboxylic and alpha-silyl-alpha-alkylcarboxylic acids including some known alpha-silyl(cycloalkyl)carboxylic acids have been prepared by different synthetic methods. The anodic oxidation in basic methanol of selected examples of these acids has been investigated under various experimental conditions to afford mainly oxidative degermylation/desilylation and decarboxylation products. Based on the emerged products, various mechanisms are suggested and discussed. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2011.12.025
• 作为产物：
  描述：

  (三甲基甲硅烷基）乙酸 、 三甲基氯化锗 在 diisopropyl amine 、 n-butyllithium 作用下， 以 四氢呋喃 为溶剂， 以80%的产率得到Trimethylgermyl-essigsaeure
  参考文献：
  名称：

  Synthesis of α-germyl and α-silylcarboxylic acids and selected electrochemical oxidations

  摘要：

  New alpha-germylcarboxylic acids, alpha-silyl-alpha-halocarboxylic and alpha-silyl-alpha-alkylcarboxylic acids including some known alpha-silyl(cycloalkyl)carboxylic acids have been prepared by different synthetic methods. The anodic oxidation in basic methanol of selected examples of these acids has been investigated under various experimental conditions to afford mainly oxidative degermylation/desilylation and decarboxylation products. Based on the emerged products, various mechanisms are suggested and discussed. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2011.12.025

文献信息

• Synthesis of α-germyl and α-silylcarboxylic acids and selected electrochemical oxidations
  作者：Anna Rakovshik、Alex V. Shtelman、James Y. Becker

  DOI：10.1016/j.jorganchem.2011.12.025

  日期：2012.6

  New alpha-germylcarboxylic acids, alpha-silyl-alpha-halocarboxylic and alpha-silyl-alpha-alkylcarboxylic acids including some known alpha-silyl(cycloalkyl)carboxylic acids have been prepared by different synthetic methods. The anodic oxidation in basic methanol of selected examples of these acids has been investigated under various experimental conditions to afford mainly oxidative degermylation/desilylation and decarboxylation products. Based on the emerged products, various mechanisms are suggested and discussed. (C) 2011 Elsevier B. V. All rights reserved.