2-(3,4-Dimethoxyphenyl)-4-(2-piperidin-1-ylethyl)imidazo[1,2-a]benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(3,4-Dimethoxyphenyl)-4-(2-piperidin-1-ylethyl)imidazo[1,2-a]benzimidazole
• 化学式: C₂₄H₂₈N₄O₂
• 分子量: 404.512
• InChiKey: CWSWNOVHCWTWCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  43.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-硝基糠醛 、 2-(3,4-Dimethoxyphenyl)-4-(2-piperidin-1-ylethyl)imidazo[1,2-a]benzimidazole 以 乙醇 为溶剂， 以73%的产率得到{2-(3,4-dimethoxyphenyl)-9-[2-(piperidin-1-yl)-ethyl]-9H-imidazo[1,2-a]benzimidazol-3-yl}(5-nitrofuran-2-yl)methanol
  参考文献：
  名称：

  Synthesis of 9-Substituted Imidazo[1,2-a]benzimidazoles Containing a 5-Nitrofuran-2-yl Fragment

  摘要：

  9-Substituted 2-(5-nitrofuran-2-yl)-9H-imidazo[1,2-a]benzimidazoles were synthesized for the first time by cyclization of quaternary salts obtained from 1-substituted benzimidazol-2-amines and 2-bromo-1-(5-nitrofuran-2-yl)ethan-1-one. 9-R-2-Methyl(aryl)-9H-imidazo[1,2-a]benzimidazoles reacted with 5-nitrofuran2-carbaldehyde and 4-nitrobenzaldehyde to give the corresponding secondary alcohols as a result of aldehyde addition to the 3-position of the tricyclic system. The Witting olefination of ethyl 2-(bromomethyl)-9-methyl-9H-imidazo[1,2-a]benzimidazole-3-carboxylate afforded 2-ethenylimidazo[1,2-a]benzimidazoles.

  DOI：

  10.1134/s1070428019100130