5-戊基噻唑 | 96693-93-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-戊基噻唑
• 英文名称: 5-Pentyl-1,3-thiazole
• CAS: 96693-93-5
• 化学式: C₈H₁₃NS
• 分子量: 155.26
• InChiKey: GSIZIOFGSQLTRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES<br/>[FR] DÉRIVÉS DE 2-AZA-BICYCLO[2.2.1]HEPTANE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2009104155A1

  公开（公告）日：2009-08-27

  The invention relates to novel 2-aza-bicyclo[2.2.1]heptane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

  这项发明涉及公式（I）中的新型2-aza-双环[2.2.1]庚烷衍生物，其中A、B、n和R1如描述中所述，并且涉及将这类化合物或这类化合物的药用盐用作药物，特别是用作促觉醒素受体拮抗剂。
• Thiazole Amides, Imidazole Amides and Related Analogues
  申请人：Pringle Wallace C.

  公开号：US20100297035A1

  公开（公告）日：2010-11-25

  Thiazole amides, imidazole amides and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

  本发明提供了式子中所述的噻唑酰胺、咪唑酰胺及其相关类似物，其中变量如本文所述。这些化合物可用于调节组织胺H3受体在体内或体外的配体结合，并且在治疗人类、家畜宠物和牲畜等各种中枢神经系统（CNS）和其他疾病中特别有用。本文提供的化合物可单独或与一个或多个其他CNS药剂联合使用以增强其他CNS药剂的效果。本文还提供了用于治疗此类疾病的制药组合物和方法，以及用于检测组织胺H3受体的配体（例如受体定位研究）的方法。
• PI-kinase inhibitors with anti-infective activity
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10428060B2

  公开（公告）日：2019-10-01

  Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole or a 5-hetereoaryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.

  本文提供了用于治疗病原体感染的化合物和方法。在一些实施方案中，抗感染化合物对各种感染性疾病具有广谱活性，其中这些疾病是由含有碱性氨基酸 PIP-2 钳子（BAAPP）结构域的病原体引起的，该结构域与磷脂酰肌醇 4,5-二磷酸（PIP-2）相互作用，介导病原体的复制。还提供了抑制 PI4 激酶的方法和抑制病毒感染的方法。在某些实施方案中，化合物是一种 PI4- 激酶抑制化合物，它是一种 5-芳基噻唑或 5-对位芳基噻唑。主体化合物可与第二种抗感染剂，如干扰素、利比伐林等结合配制或提供给主体。
• PEPTIDE ISOTERS CONTAINING A HETEROCYCLE AS H.I.V. INHIBITORS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0603309A1

  公开（公告）日：1994-06-29
• HIV PROTEASE INHIBITORS CONTAINING GUANIDINE
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0610431A1

  公开（公告）日：1994-08-17