2-(2-Methyl-1,3-dioxolan-2-yl)pentanoic acid | 854133-00-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(2-Methyl-1,3-dioxolan-2-yl)pentanoic acid
• 英文别名: 2-(2-methyl-1,3-dioxolan-2-yl)pentanoic acid
• CAS: 854133-00-9
• 化学式: C₉H₁₆O₄
• 分子量: 188.224
• InChiKey: ROSGVSHAJCDERQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-Methyl-1,3-dioxolan-2-yl)pentanoic acid 在 吡啶 、 三氯化铝 、 草酰氯 、 氨 、 对甲苯磺酸 作用下， 以 乙醚 、 二氯甲烷 、 丙酮 为溶剂， 反应 17.0h， 生成
  参考文献：
  名称：

  Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones

  摘要：

  Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.054
• 作为产物：
  描述：

  2-丙基乙酰乙酸乙酯 在 氢氧化钾 、 对甲苯磺酸 作用下， 以 1,4-二氧六环 、 甲苯 为溶剂， 反应 12.0h， 生成 2-(2-Methyl-1,3-dioxolan-2-yl)pentanoic acid
  参考文献：
  名称：

  Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones

  摘要：

  Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.054

文献信息

• [EN] TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF<br/>[FR] SYNTHÈSE TOTALE DE SALINOSPORAMIDE A ET DE SES ANALOGUES
  申请人：NEREUS PHARMACEUTICALS INC

  公开号：WO2009134531A2

  公开（公告）日：2009-11-05

  The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).
• Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones
  作者：Irina Shcherbakova、Guangfei Huang、Otto J. Geoffroy、Satheesh K. Nair、Krzysztof Swierczek、Manuel F. Balandrin、John Fox、William L. Heaton、Rebecca L. Conklin

  DOI：10.1016/j.bmcl.2005.03.054

  日期：2005.5

  Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described. (c) 2005 Elsevier Ltd. All rights reserved.