2-[2-(3,5-Dimethoxy-4-oxidanyl-phenyl)-3-[6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-7-oxidanyl-chromenylium-5-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol chloride

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-[2-(3,5-Dimethoxy-4-oxidanyl-phenyl)-3-[6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-7-oxidanyl-chromenylium-5-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol chloride
• 英文别名: 2-[7-hydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromenylium-5-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;chloride
• 化学式: C29H35ClO17
• 分子量: 691.0
• InChiKey: RHKJIVJBQJXLBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.83
• 重原子数：
  47
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  259
• 氢给体数：
  10
• 氢受体数：
  17

文献信息

• [EN] METHOD FOR PREPARATION OF 3,7-BIS-(DIMETHYLAMINO)-PHENOTHIAZIN-5-IUM CHLORIDE OR BROMIDE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE CHLORURE OU BROMURE DE 3,7-BIS-(DIMÉTHYLAMINO)-PHÉNOTHIAZIN-5-IUM
  申请人：MIKROCHEM SPOL S R O

  公开号：WO2018167185A1

  公开（公告）日：2018-09-20

  The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5- ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis- (dimethylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(dimethylamino)-phenothiazin- 5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.

  本发明涉及：制备3,7-双-(二甲氨基)-苯并噻嗪-5- 唑溴化物或氯化物的方法；将3,7-双-(二甲氨基)-苯并噻嗪-5-唑溴化物转化为3,7-双-(二甲氨基)-苯并噻嗪-5-唑氯化物的方法；以及通过从盐酸水溶液中结晶纯化7-双-(二甲氨基)-苯并噻嗪-5-唑氯化物，得到药用可接受的3,7-双-(二甲氨基)-苯并噻嗪-5-唑氯化物（甲硫鸟苷氯化物，亚甲基蓝，MTC）的方法。
• MANUFACTURING METHOD FOR POLYPHENOL COMPOSITION
  申请人：Yamada Yasushi

  公开号：US20130085270A1

  公开（公告）日：2013-04-04

  A method for producing a polyphenol composition including a step of subjecting (A) a hardly water-soluble polyphenol and (B) one or more selected from cathechins, chlorogenic acids and methylated compounds of hardly water-soluble polyphenols to a heat treatment at from 100 to 180° C. in the presence of an aqueous medium.

  一种生产多酚组合物的方法，包括以下步骤：在水介质中，在100至180°C的温度下，将（A）一种难溶于水的多酚和（B）从儿茶素、绿原酸和难溶于水的多酚的甲基化化合物中选择一种或多种进行热处理。
• [EN] ACCELERATING REPAIR OF MUCOSAL INJURY USING GOLD(III) COMPOUNDS<br/>[FR] ACCÉLÉRATION DE RÉPARATION DE LÉSION DES MUQUEUSES À L'AIDE DE COMPOSÉS D'OR (III)
  申请人：UNIV KENTUCKY RES FOUND

  公开号：WO2022026757A1

  公开（公告）日：2022-02-03

  A method of increasing mitochondrial respiration in a cell makes use of a compound having the structure of formula (I) or formula (II).

  一种增加细胞线粒体呼吸的方法利用具有公式（I）或公式（II）结构的化合物。
• Pharmaceutical composition containing substance inhibiting HSP47 production
  申请人：Kureha Chemical Industry Co., Ltd.

  公开号：EP0742012A2

  公开（公告）日：1996-11-13

  A pharmaceutical composition comprising a substance inhibiting HSP47 production, selected from the group consisting of a malt extract, a flavonoid compound, a protein-bound-polysaccharide obtained from a fungus belonging to Coriolus versicolor, a paeoniflorin derivative, a tocopherol derivative, and a ferulic acid derivative, and a pharmaceutically acceptable carrier is disclosed. The substance inhibiting HSP47 production can efficiently improve physiological conditions of a patient suffering from diseases exhibiting pathosis of overproduction of the extracellular matrix, and efficiently treat such diseases. Further, the substance is useful for preventing or treating various diseases accompanied with abnormal growth of the vascularization.

  本发明公开了一种药物组合物，该组合物包含一种抑制 HSP47 生成的物质，该物质选自麦芽提取物、黄酮类化合物、从属于 Coriolus versicolor 的真菌中获得的蛋白结合多糖、芍药苷衍生物、生育酚衍生物和阿魏酸衍生物组成的组，以及一种药学上可接受的载体。这种抑制 HSP47 生成的物质可以有效改善患有细胞外基质过度生成病症的患者的生理状况，并有效治疗此类疾病。此外，该物质还可用于预防或治疗伴有血管异常生长的各种疾病。
• Neurotransmitter stimulation of neurons with feedback from sensors
  申请人：Interuniversitair Micro-Elektronica Centrum

  公开号：EP1743665A1

  公开（公告）日：2007-01-17

  The present invention provides a system (10) for release of neurotransmitters (3) and a method for the manufacturing of such a system. The system according to the present invention allows for local release of neurotransmitters and therefor makes it possible to activate single neurons (12). Furthermore, the system according to the invention is efficient, reproducible, and has a low power supply.

  本发明提供了一种释放神经递质（3）的系统（10）和制造这种系统的方法。本发明的系统可以在局部释放神经递质，因此可以激活单个神经元（12）。此外，本发明的系统效率高、可重现性好、耗电量低。

表征谱图