N-cyclopentyl-2-(4-fluorophenyl)-3-(6-fluoropyridin-3-yl)pyrazolo[1,5-a]pyridin-7-amine | 942937-46-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-cyclopentyl-2-(4-fluorophenyl)-3-(6-fluoropyridin-3-yl)pyrazolo[1,5-a]pyridin-7-amine
• CAS: 942937-46-4
• 化学式: C₂₃H₂₀F₂N₄
• 分子量: 390.435
• InChiKey: NQOWZGSVFDVMAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-cyclopentyl-2-(4-fluorophenyl)-3-(6-fluoropyridin-3-yl)pyrazolo[1,5-a]pyridin-7-amine 、 环戊胺 反应 120.0h， 以99%的产率得到N-cyclopentyl-3-[6-(cyclopentylamino)pyridin-3-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-7-amine
  参考文献：
  名称：

  Pyrazolo[1,5-a]pyridine antiherpetics: Effects of the C3 substituent on antiviral activity

  摘要：

  A recently disclosed series of pyrazolo[1,5-a]pyridine inhibitors of herpes virus replication has been closely examined herein for effects of the C3 substituent on antiviral activity. Significant changes in activity are observed by alterations of the hetero-atom basicity and orientation of the group at C3. These results in combination with previous studies have served to further elaborate the minimal pharmacophore required for potency of this novel series of antiviral agents. During the course of these studies, several novel synthetic approaches were developed and are described. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.058
• 作为产物：
  描述：

  2-氟-5-溴吡啶 在 bis-triphenylphosphine-palladium(II) chloride 正丁基锂 、 sodium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 N-cyclopentyl-2-(4-fluorophenyl)-3-(6-fluoropyridin-3-yl)pyrazolo[1,5-a]pyridin-7-amine
  参考文献：
  名称：

  Pyrazolo[1,5-a]pyridine antiherpetics: Effects of the C3 substituent on antiviral activity

  摘要：

  A recently disclosed series of pyrazolo[1,5-a]pyridine inhibitors of herpes virus replication has been closely examined herein for effects of the C3 substituent on antiviral activity. Significant changes in activity are observed by alterations of the hetero-atom basicity and orientation of the group at C3. These results in combination with previous studies have served to further elaborate the minimal pharmacophore required for potency of this novel series of antiviral agents. During the course of these studies, several novel synthetic approaches were developed and are described. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.058

文献信息

• Pyrazolo[1,5-a]pyridine antiherpetics: Effects of the C3 substituent on antiviral activity
  作者：Brian A. Johns、Kristjan S. Gudmundsson、Scott H. Allen

  DOI：10.1016/j.bmcl.2007.02.058

  日期：2007.5

  A recently disclosed series of pyrazolo[1,5-a]pyridine inhibitors of herpes virus replication has been closely examined herein for effects of the C3 substituent on antiviral activity. Significant changes in activity are observed by alterations of the hetero-atom basicity and orientation of the group at C3. These results in combination with previous studies have served to further elaborate the minimal pharmacophore required for potency of this novel series of antiviral agents. During the course of these studies, several novel synthetic approaches were developed and are described. (c) 2007 Elsevier Ltd. All rights reserved.