5-Hydroxy-3,4,6-trimethylindoline | 181420-39-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-Hydroxy-3,4,6-trimethylindoline
• 英文别名: 3,4,6-trimethyl-2,3-dihydro-1H-indol-5-ol
• CAS: 181420-39-3
• 化学式: C₁₁H₁₅NO
• 分子量: 177.246
• InChiKey: XWXZZIYQBKTHOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  吲哚啉 、 5-Hydroxy-3,4,6-trimethylindoline 在 吡啶 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 N-isobutyryl-5-hydroxy-3,4,6-trimethylindoline
  参考文献：
  名称：

  .rho.-heteroatom-substituted phenols and uses thereof

  摘要：

  本发明提供了一种具有结构式的抗增殖p-杂原子取代酚化合物##STR1##其中m为0至3，n为0至4，当Het为氮时，其中R选自氢、烷基、芳基甲基和酰基组成的群；R.sup.1为烷基；R.sup.2选自氢和烷基；R.sup.3选自烷基和酰基，当Het为氮时，R.sup.4选自氢和烷基；R.sup.5选自氢和烷基；以及R.sup.6和R.sup.7选自氢、烷基和R.sup.6和R.sup.7可以一起代表氧。还提供了治疗病理细胞增生性疾病的各种方法，包括向动物)施用含有p-杂原子取代酚或其类似物的药物组成的药物学和治疗学有效剂量。

  公开号：

  US05674876A1

文献信息

• US5674876A
  申请人：——

  公开号：US5674876A

  公开（公告）日：1997-10-07
• [EN] DYE COMPOSITION USING A (HYDROXY)INDOLINE COUPLER IN A MEDIUM RICH IN FATTY SUBSTANCES, PROCESS AND DEVICES<br/>[FR] COMPOSITION DE COLORATION UTILISANT UN COUPLEUR (HYDROXY)INDOLINE DANS UN MILIEU RICHE EN SUBSTANCES GRASSES, PROCÉDÉ ET DISPOSITIF
  申请人：OREAL

  公开号：WO2012163898A1

  公开（公告）日：2012-12-06

  The present invention relates to a composition for dyeing keratin fibres, comprising: at least one fatty substance, at least one surfactant; at least one oxidation base, at least one indoline coupler of formula (B7) or of formula (B8), and also salts thereof, optical and geometrical isomers and tautomers thereof, and hydrates thereof, formulae (B7) and (B8) being the following: at least one basifying agent; the fatty substance content representing in total at least 25% by weight relative to the total weight of the composition; at least one oxidation base being chosen from heterocyclic oxidation bases when the coupler is of formula (B7). The present invention also relates to a process using this composition in the presence of at least one chemical oxidizing agent, and to multi-compartment devices suitable for the implementation of the invention.
• .rho.-heteroatom-substituted phenols and uses thereof
  申请人：Research Development Foundation

  公开号：US05674876A1

  公开（公告）日：1997-10-07

  The present invention provides an antiproliferative p-heteroatom-substituted phenol compound having the structure formula ##STR1## wherein m is 0 to 3, n is 0 to 4 when Het is nitrogen, wherein R is selected from the group consisting of hydrogen, alkyl, arylmethyl and acyl; R.sup.1 is alkyl; R.sup.2 is selected from the group consisting of hydrogen and alkyl; R.sup.3 is selected from the group consisting of alkyl and acyl when Het is nitrogen, R.sup.4 is selected from the group consisting of hydrogen and alkyl; R.sup.5 is selected from the group consisting of hydrogen and alkyl; and R.sup.6 and R.sup.7 are selected from the group consisting of hydrogen, alkyl and R.sup.6 and R.sup.7 together may represent oxygen. Also provided are various methods for the treatment of a pathological cell proliferative disease comprising administering to an animal) a pharmacologically and therapeutically effective dose of a pharmaceutical composition comprising a p-heteroatom-substituted phenols or an analog thereof.

  本发明提供了一种具有结构式的抗增殖p-杂原子取代酚化合物##STR1##其中m为0至3，n为0至4，当Het为氮时，其中R选自氢、烷基、芳基甲基和酰基组成的群；R.sup.1为烷基；R.sup.2选自氢和烷基；R.sup.3选自烷基和酰基，当Het为氮时，R.sup.4选自氢和烷基；R.sup.5选自氢和烷基；以及R.sup.6和R.sup.7选自氢、烷基和R.sup.6和R.sup.7可以一起代表氧。还提供了治疗病理细胞增生性疾病的各种方法，包括向动物)施用含有p-杂原子取代酚或其类似物的药物组成的药物学和治疗学有效剂量。