(R,S)-3-ethyl-4-aminobutyric acid | 131683-06-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R,S)-3-ethyl-4-aminobutyric acid
• 英文别名: 4-Amino-3-ethyl-buttersaeure；4-amino-3-ethylbutanoic acid；3-(Azaniumylmethyl)pentanoate
• CAS: 131683-06-2
• 化学式: C₆H₁₃NO₂
• mdl: MFCD19204274
• 分子量: 131.175
• InChiKey: MVIPFBVXMASPHV-UHFFFAOYSA-N

物化性质

• 沸点：
  203 °C
• 密度：
  1.038±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-乙基-2-吡咯烷酮 在 盐酸 作用下， 生成 (R,S)-3-ethyl-4-aminobutyric acid
  参考文献：
  名称：

  Colonge,J.; Pouchol,J.-M., Bulletin de la Societe Chimique de France, 1962, p. 598 - 603

  摘要：

  DOI：

文献信息

• EFTU INHIBITORS OR AMINOTHIAZOLES AND THEIR USES
  申请人：LaMarche Matthew J.

  公开号：US20080221142A1

  公开（公告）日：2008-09-11

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.

  本申请描述了对治疗、预防和/或改善疾病有用的有机化合物。
• SILICON-CONTAINING CARBOXYLIC ACID DERIVATIVE
  申请人：Muratake Hideaki

  公开号：US20140031575A1

  公开（公告）日：2014-01-30

  A compound represented by the formula (I) [R 1 to R 8 represent an alkyl group, an alkenyl group, and the like; n represents 0 or 1; R 4 represents an amino group or —(CX 2 ) m —COOH (m represents 0 to 3, and X represents hydrogen atom); R 5 represents —(CY 2 ) p —COOR 6 (p represents an 0 to 3, Y represents hydrogen atom, and R 6 represents hydrogen atom or an alkyl group)], or a salt thereof.

  由式(I)表示的化合物[R1至R8表示烷基基团、烯基基团等；n表示0或1；R4表示氨基团或—(CX2)m—COOH（m表示0到3，X表示氢原子）；R5表示—(CY2)p—COOR6（p表示0到3，Y表示氢原子，R6表示氢原子或烷基基团）]，或其盐。
• A Convenient Synthesis of 3-Alkyl-4-aminobutanoic Acids
  作者：Ryszard Andruszkiewicz、Richard B. Silverman

  DOI：10.1055/s-1989-27443

  日期：——

  A series of 3-alkyl-4-aminobutanoic acids were prepared via the Michael addition of nitromethane to 2-alkenoic esters, followed by catalytic hydrogenation of the resultant 3-(nitromethyl)alkanoic esters using 10% palladium on carbon in acetic acid, and acid hydrolysis of the reduction products.

  一系列3-烷基-4-氨基丁酸通过将亚硝基甲烷与2-烯酸酯进行迈克尔加成反应制备而成，随后使用10%的碳基钯催化剂在醋酸中对生成的3-(亚硝基甲基)烷酸酯进行催化氢化，并对还原产物进行酸水解。
• AMINOTHIAZOLES AND THEIR USES
  申请人：Bushell Simon

  公开号：US20140315790A1

  公开（公告）日：2014-10-23

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.

  本申请描述了对治疗、预防和/或改善疾病有用的有机化合物。
• Diagnostic and therapeutic agents
  申请人：Taube Seija

  公开号：US20070258899A1

  公开（公告）日：2007-11-08

  Tumor targeting units are disclosed which have a peptide sequence C y —Y—G-F—X—W-G-Z-C yy (SEQ ID NO: 25), or a pharmaceutically or physiologically acceptable salt thereof. Tumor targeting agents are also disclosed having at least one targeting unit, directly or indirectly coupled to at least one effector unit. Diagnostic or pharmaceutical compositions having at least one targeting unit or at least one targeting agent, and targeting units or targeting agents for the preparation of a medicament for the treatment of cancer related diseases (including cancer), especially for the treatment of colon/colorectal cancer or its metastases are also disclosed.

  揭示了具有肽序列Cy—Y—G-F—X—W-G-Z-Cyy（序列ID编号：25）或其药学或生理上可接受的盐的肿瘤靶向单元。还披露了具有至少一个靶向单元的肿瘤靶向剂，直接或间接地偶联至至少一个效应单元。还披露了具有至少一个靶向单元或至少一个靶向剂的诊断或药物组合物，以及用于制备治疗癌症相关疾病（包括癌症）的药物的靶向单元或靶向剂，特别是用于治疗结肠/结直肠癌或其转移的靶向单元或靶向剂。