N-cinnamoylleucine methyl ester | 127852-93-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-cinnamoylleucine methyl ester
• 英文别名: N-cinnamoyl-D,L-leucine methyl ester；methyl 4-methyl-2-[[(E)-3-phenylprop-2-enoyl]amino]pentanoate
• CAS: 127852-93-1
• 化学式: C₁₆H₂₁NO₃
• 分子量: 275.348
• InChiKey: OXFYLVKTVPTJPQ-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-cinnamoylleucine methyl ester 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 3.0h， 以100%的产率得到N-cinnamoylleucine
  参考文献：
  名称：

  杂环作为掩蔽二酰胺/二肽等价物。取代的 5-（酰氨基）恶唑作为中间体在制备环肽生物碱的过程中的形成和反应

  摘要：

  从二烷基-2,4 酰基氨基-5 恶唑环化到部分 d'α-氰基烷基酰胺 d'酸、去 N-乙酰 α-氨基酰胺或二肽合成练习曲。钝性恶唑功能化

  DOI：

  10.1021/ja00364a041
• 作为产物：
  描述：

  肉桂酸 、 2-氨基-4-甲基戊酸盐酸盐 在 三乙胺 、 氯甲酸异丁酯 作用下， 以 乙腈 为溶剂， 以65.3%的产率得到N-cinnamoylleucine methyl ester
  参考文献：
  名称：

  Synthesis of pseudosparsomycins

  摘要：

  DOI：

  10.1007/bf00764814

文献信息

• NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF
  申请人：Tachdjian Catherine

  公开号：US20120201763A1

  公开（公告）日：2012-08-09

  The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

  本发明涉及到一些非自然生成、非肽酰胺化合物和酰胺衍生物的发现，例如草酰胺、脲和丙烯酰胺，这些化合物是有用的味道或口感调节剂，例如调味剂和增味剂，更特别地，是鲜味（单钠谷氨酸的“鲜味”）或甜味调节剂，- 鲜味或甜味调味剂和鲜味或甜味增强剂，用于食品、饮料和其他可食用或口服药物产品或组合物。
• T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
  申请人：SENOMYX, INC.

  公开号：US10352929B2

  公开（公告）日：2019-07-16

  The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.

  本发明涉及与 T1R1/T1R3 或 T1R2/T1R3 受体或其片段或亚单位特异性结合的化合物。本发明还涉及在测定中使用包含 T1R1/T1R3 和 T1R2/T1R3 的异源同源体和嵌合味觉受体，以鉴定分别对鲜味刺激和甜味刺激做出反应的化合物。此外，本发明还涉及在组成型或诱导型条件下稳定或瞬时共表达 T1R1 和 T1R3 或 T1R2 和 T1R3 组合的细胞系的组成。本发明还提供了在基于细胞的检测中使用这些细胞系鉴定鲜味和甜味调节化合物的方法，特别是通过荧光成像检测受体活性的高通量筛选检测方法。
• ARUTYUNYAN, A. A.;MELIK-OGADZHANYAN, R. G.;ALAVERDOVA, L. G.;PAPOYAN, S. +, XIM.-FARMATS. ZH., 23,(1989) N0, S. 1223-1226
  作者：ARUTYUNYAN, A. A.、MELIK-OGADZHANYAN, R. G.、ALAVERDOVA, L. G.、PAPOYAN, S. +

  DOI：——

  日期：——
• CHIMERIC T1R TASTE RECEPTOR POLYPEPTIDES AND NUCLEIC ACID SEQUENCES ENCODING AND CELL LINES THAT EXPRESS SAID CHIMERIC T1R POLYPEPTIDES
  申请人：LI Xiaodong

  公开号：US20110294981A1

  公开（公告）日：2011-12-01

  The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.
• USE OF T1R3 VENUS FLYTRAP REGION POLYPEPTIDE TO SCREEN FOR TASTE MODUALTORS
  申请人：SENOMYX, INC.

  公开号：US20150064112A1

  公开（公告）日：2015-03-05

  The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.