Methyl 1,3-bis[tri(propan-2-yl)silyl]pyrazole-4-carboxylate | 122093-33-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Methyl 1,3-bis[tri(propan-2-yl)silyl]pyrazole-4-carboxylate
• CAS: 122093-33-8
• 化学式: C₂₃H₄₆N₂O₂Si₂
• 分子量: 438.801
• InChiKey: GVIXNRXSCBJBHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.58
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (triisopropylsilyl)diazomethane 在 二苯并-18-冠醚-6 、 正丁基锂 作用下， 以 苯 为溶剂， 生成 Methyl 1,3-bis[tri(propan-2-yl)silyl]pyrazole-4-carboxylate
  参考文献：
  名称：

  Synthesis and reactivity of stable silyl-substituted nitrilimines

  摘要：

  The reaction of chlorophosphanes and chlorosilanes with the lithium salts of the (bis(diisopropylamino)-thiophosphoranyl)-, bis(diisopropylamino)phosphanyl)-, (trimethylsilyl)-, and (triisopropylsilyl)diazomethane (1, 4, 5, 6) has been studied. Four isolable nitrilimines XCNNY (X = (iPr2N)2P(S), Y = SiiPr3, 10a; X = (iPr2N)2P, Y = SiPh3, 14a; X = (iPr2N)2P, Y = SiiPr3, 15a; X = Y = SiiPr3, 18a) and three observable nitrilimines (X = (iPr2N)2P(S), Y = SiMe3, 8a; X = (iPr2N)2P(S), Y = SiPh3, 9a; X = (iPr2N)2P, Y = SiMe3, 13a) have been obtained. The factors influencing the stability of nitrilimines are analyzed. Several examples of thermal nitrilimine-diazo rearrangements and photochemical nitrilimine-carbodiimide rearrangements are described. The regioselectivity of the reaction of the observable nitrilimines with methyl acrylate and methyl propiolate is compared to that reported for transient nitrilimines. An example of 1,3-addition of butyllithium to a nitrilimine is given.

  DOI：

  10.1021/jo00005a026

文献信息

• Castan, Florence; Baceiredo, Antoine; Bertrand, Guy, Angewandte Chemie, 1989, vol. 101, # 9, p. 1253 - 1254
  作者：Castan, Florence、Baceiredo, Antoine、Bertrand, Guy

  DOI：——

  日期：——
• CASTAN, FLORENCE;BACEIREDO, ANTOINE;BERTRAND, GUY, ANGEW. CHEM., 101,(1989) N, C. 1253-1255
  作者：CASTAN, FLORENCE、BACEIREDO, ANTOINE、BERTRAND, GUY

  DOI：——

  日期：——
• CASTAN, FLORENCE;BACEIREDO, ANTOINE;BIGG, DENNIS;BERTRAND, G., J. ORG. CHEM., 56,(1991) N, C. 1801-1807
  作者：CASTAN, FLORENCE、BACEIREDO, ANTOINE、BIGG, DENNIS、BERTRAND, G.

  DOI：——

  日期：——