tert-butyl 2-pivaloylhydrazinecarboxylate | 1244059-26-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl 2-pivaloylhydrazinecarboxylate
• 英文别名: tert-butyl 2-(2,2-dimethylpropanoyl)hydrazinecarboxylate；tert-butyl N-(2,2-dimethylpropanoylamino)carbamate
• CAS: 1244059-26-4
• 化学式: C₁₀H₂₀N₂O₃
• mdl: MFCD02310058
• 分子量: 216.28
• InChiKey: CFXLEMZNWBHNQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl 2-pivaloylhydrazinecarboxylate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 生成 pivalohydrazide hydrochloride
  参考文献：
  名称：

  [EN] FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE
  [FR] COMPOSÉS BICYCLIQUES FUSIONNÉS UTILISÉS COMME INHIBITEURS DE LA PI3 KINASE

  摘要：

  该发明涉及用于调节磷脂酰肌醇3-激酶活性及相关疾病的化合物（I）的公式。

  公开号：

  WO2010100144A1
• 作为产物：
  描述：

  肼基甲酸叔丁酯 、 三甲基乙酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.17h， 以70%的产率得到tert-butyl 2-pivaloylhydrazinecarboxylate
  参考文献：
  名称：

  [EN] FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE
  [FR] COMPOSÉS BICYCLIQUES FUSIONNÉS UTILISÉS COMME INHIBITEURS DE LA PI3 KINASE

  摘要：

  该发明涉及用于调节磷脂酰肌醇3-激酶活性及相关疾病的化合物（I）的公式。

  公开号：

  WO2010100144A1

文献信息

• FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS
  申请人：HANDOK INC.

  公开号：US20160168156A1

  公开（公告）日：2016-06-16

  The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases. In some compounds of Formula I, Q is —CH═CR 3 C(O)NR 4 R 5 , —C≡CC(O)NR 4 R 5 , or

  该披露提供了由化学式I或其药用可接受的盐、溶剂化合物、多型体、酯、互变异构体或前药表示的新型化合物。这些化合物可用作Trk的抑制剂，并且在治疗疼痛、癌症、炎症、神经退行性疾病和某些传染病方面是有用的。 在化合物I的某些化合物中，Q为—CH═CR3C(O)NR4R5，—C≡CC(O)NR4R5，或...
• Diphenylmethane Derivatives as Inhibitors of Leukotriene Biosynthesis
  申请人：Armstrong Helen M.

  公开号：US20090258885A1

  公开（公告）日：2009-10-15

  The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.

  本发明提供了公式I的化合物，这些化合物是5-脂氧合酶活化蛋白抑制剂。公式I的化合物可用作抗动脉粥样硬化、抗哮喘、抗过敏、抗炎和细胞保护剂。
• Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative
  申请人：Vidal Laurent

  公开号：US20080071092A1

  公开（公告）日：2008-03-20

  Disclosed herein are a composition for dyeing keratinous fibers, for example, human keratinous fibers such as hair, comprising at least one oxidation base chosen from diamino-N,N-dihydropyrazolone derivative and a method using the composition. Further disclosed herein are amino-N,N-dihydropyrazolone derivatives and the addition salts thereof and diamino-N,N-dihydropyrazolone derivatives and the addition salts thereof, as well as the methods for preparing these compounds.
• IONIC LIQUID SUPPORTED ORGANOTIN REAGENTS FOR THE MANUFACTURING OF RADIOPHARMACEUTICALS COMPOUNDS
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS

  公开号：US20160326194A1

  公开（公告）日：2016-11-10

  An ionic liquid supported organotin reagent of formula (I) A process for manufacturing the ionic liquid supported organotin reagent of formula (I), a process for manufacturing an halogenated or radio-halogenated compound using compound of formula (I), a device for implementing the halogenating process and a kit including the compound of formula (I) are also described.
• US9701681B2
  申请人：——

  公开号：US9701681B2

  公开（公告）日：2017-07-11