4-[[6-(4-Fluoroanilino)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl]amino]-1,5-dimethyl-2-phenylpyrazol-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[[6-(4-Fluoroanilino)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl]amino]-1,5-dimethyl-2-phenylpyrazol-3-one
• 化学式: C₂₁H₁₇FN₈O₂
• mdl: MFCD01029807
• 分子量: 432.4
• InChiKey: PJFHNKKDSNQTPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS
  申请人：Compass Pharmaceuticals LLC

  公开号：EP1799689A1

  公开（公告）日：2007-06-27
• Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents
  申请人：Baures Paul W.

  公开号：US20090131445A1

  公开（公告）日：2009-05-21

  The present invention provides novel compounds of the formula (I) and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but are not limited to sarcomas, melanomas, neuroblastomas, carcinomas (including but not limited to lung, renal cell, ovarian, liver, bladder, and pancreatic carcinomas), and mesotheliomas.
• [EN] FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS<br/>[FR] FURAZANO-3,4-BIPYRAZINES ET LEUR EMPLOI EN TANT QU'AGENTS ANTITUMORAUX
  申请人：COMPASS PHARMACEUTICALS LLC

  公开号：WO2006044402A1

  公开（公告）日：2006-04-27

  [EN] The present invention provides novel compounds of the formula (I) and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but are not limited to sarcomas, melanomas, neuroblastomas, carcinomas (including but not limited to lung, renal cell, ovarian, liver, bladder, and pancreatic carcinomas), and mesotheliomas.
  [FR] La présente invention décrit de nouveaux composés de formule (I) et des préparations pharmaceutiques incluant lesdits composés, ainsi que des méthodes permettant d'employer lesdits composés et lesdites préparations pharmaceutiques dans le traitement de tumeurs. Lesdits composés peuvent être employés afin de traiter des tumeurs spécifiques, par exemple les sarcomes, les mélanomes, les neuroblastomes, les carcinomes (incluant sans y être limités les carcinomes du poumon, des cellules rénales, ovariens, du foie, de la vessie, et pancréatiques) et les mésothéliomes.