2-Oxo-4-thiophen-3-ylbut-3-enoic acid | 776260-67-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2-Oxo-4-thiophen-3-ylbut-3-enoic acid
• CAS: 776260-67-4
• 化学式: C₈H₆O₃S
• 分子量: 182.2
• InChiKey: VZHDNOQRJQEDNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Oxo-4-thiophen-3-ylbut-3-enoic acid 、 (S)-N-((3-(3-氟-4-(哌嗪-1-基)苯基)-2-氧代噁唑啉-5-基)甲基)乙酰胺 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 生成
  参考文献：
  名称：

  Novel 4-N-substituted aryl but-3-ene-1,2-dione derivatives of piperazinyloxazolidinones as antibacterial agents

  摘要：

  Novel (5S)-N-[3-(3-fluoro-4-{4-[2-oxo-4-(substituted aryl)-but-3-enoyl]-piperazin-1-yl}-phenyl)-2-oxooxazolidin-5-ylmethyl]-acetamide 3a-j analogues were synthesized and their in vitro antibacterial activity was evaluated. Most of the compounds of series showed superior in vitro activity against Gram-positive resistant strains than linezolid. Compound 3f is the most potent compound in the series with 0.040.39 mu g/mL MIC. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.106
• 作为产物：
  描述：

  3-噻吩甲醛 、 丙酮酸 在 potassium hydroxide 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 生成 2-Oxo-4-thiophen-3-ylbut-3-enoic acid
  参考文献：
  名称：

  Novel 4-N-substituted aryl but-3-ene-1,2-dione derivatives of piperazinyloxazolidinones as antibacterial agents

  摘要：

  Novel (5S)-N-[3-(3-fluoro-4-{4-[2-oxo-4-(substituted aryl)-but-3-enoyl]-piperazin-1-yl}-phenyl)-2-oxooxazolidin-5-ylmethyl]-acetamide 3a-j analogues were synthesized and their in vitro antibacterial activity was evaluated. Most of the compounds of series showed superior in vitro activity against Gram-positive resistant strains than linezolid. Compound 3f is the most potent compound in the series with 0.040.39 mu g/mL MIC. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.106

文献信息

• MEMBRANE ACTIVE MOLECULES
  申请人：Branequest, Inc.

  公开号：EP3615084A1

  公开（公告）日：2020-03-04
• [EN] MEMBRANE ACTIVE MOLECULES<br/>[FR] MOLÉCULES ACTIVES DANS UNE MEMBRANE
  申请人：BRANEQUEST INC

  公开号：WO2018200412A1

  公开（公告）日：2018-11-01

  A method of inducing anesthesia, sedation, and a method for treating disorders including central nervous system disorder, peripheral nervous system disorder, depression ischemia, and treatment with an anticonvulsant by administering an effective amount of a compound to a subject in need thereof.