1-(tert-butylamino)-1-oxopropan-2-yl acetate | 99065-81-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(tert-butylamino)-1-oxopropan-2-yl acetate
• 英文别名: 2-acetoxy-propionic acid tert-butylamide；2-Acetoxy-propionsaeure-tert-butylamid；2-Acetoxy-N-tert-butyl-propionamid；[1-(Tert-butylamino)-1-oxopropan-2-yl] acetate；[1-(tert-butylamino)-1-oxopropan-2-yl] acetate
• CAS: 99065-81-3
• 化学式: C₉H₁₇NO₃
• mdl: MFCD24389067
• 分子量: 187.239
• InChiKey: UYOBCWGBIJTLRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(tert-butylamino)-1-oxopropan-2-yl acetate 生成 N-叔丁基丙烯酰胺
  参考文献：
  名称：

  A New Reaction of Nitriles. VI. Unsaturated Amides¹

  摘要：

  DOI：

  10.1021/ja01153a005
• 作为产物：
  描述：

  乙酸酐 、 alkaline earth salt of/the/ methylsulfuric acid 生成 1-(tert-butylamino)-1-oxopropan-2-yl acetate
  参考文献：
  名称：

  A New Reaction of Nitriles. VI. Unsaturated Amides¹

  摘要：

  DOI：

  10.1021/ja01153a005

文献信息

• Compounds And Compositions for the Treatment of Ocular Disorders
  申请人：Graybug Vision, Inc.

  公开号：US20170080092A1

  公开（公告）日：2017-03-23

  The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.

  该披露描述了前药和前列腺素的衍生物、碳酸酐酶抑制剂、激酶抑制剂、β-肾上腺素受体拮抗剂和其他药物，以及含有这些前药和衍生物的受控释放配方，用于治疗眼部疾病。
• Supported <i>p</i>-Toluenesulfonic Acid as a Highly Robust and Eco-Friendly Isocyanide Scavenger
  作者：Jhonny Azuaje、Alberto Coelho、Abdelaziz El Maatougui、José Manuel Blanco、Eddy Sotelo

  DOI：10.1021/co100035z

  日期：2011.1.10

  We document here the use of polymer-supported p-toluenesulfonic acid as a highly effective, robust, economical and eco-friendly isocyanide scavenger. The herein described strategy; circumvent the intense and repulsive odor of volatile isocyanides, enabling simplified and odorless workup and purifications. The usefulness of the new scavengers has been validated in a set of diverse isocyanide-based organic transformations and this approach is also amenable to parallel synthesis techniques.
• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF OCULAR DISORDERS
  申请人：Graybug Vision, Inc.

  公开号：US20180028673A1

  公开（公告）日：2018-02-01

  The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.
• US9808531B2
  申请人：——

  公开号：US9808531B2

  公开（公告）日：2017-11-07
• US9956302B2
  申请人：——

  公开号：US9956302B2

  公开（公告）日：2018-05-01