benzyl (2-(((tert-butoxycarbonyl)amino)oxy)ethyl)carbamate | 1237528-53-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl (2-(((tert-butoxycarbonyl)amino)oxy)ethyl)carbamate
• 英文别名: 9,9-dimethyl-7-oxo-5,8-dioxa-2,6-diazadecanoic acid phenylmethyl ester；benzyl N-[2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyethyl]carbamate
• CAS: 1237528-53-8
• 化学式: C₁₅H₂₂N₂O₅
• 分子量: 310.35
• InChiKey: QIGAAVOMDUTGCI-UHFFFAOYSA-N

物化性质

• 密度：
  1.154±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  85.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  benzyl (2-(((tert-butoxycarbonyl)amino)oxy)ethyl)carbamate 在 三乙基硅烷 、 氯仿 、 palladium 10% on activated carbon 作用下， 以 甲醇 为溶剂， 以95%的产率得到tert-butyl 2-aminoethoxycarbamate hydrochloride
  参考文献：
  名称：

  用于生物偶联的氨基氧基和 N-烷基氨基氧基胺的合成

  摘要：

  五种 Boc 保护的氨基氧基和N-烷基氨基氧基胺已使用常见的合成策略从现成的二碳和三碳 Cbz 保护的氨基醇合成，总产率为 60-95%。胺可以通过酰胺形成与生物分子连接，并通过亚单体合成直接结合到类肽中。随后氨基氧基和N-烷基氨基氧基的脱保护能够通过已建立的化学选择性连接方法与所需的目标分子缀合。合成的衍生物的范围允许在共轭分子之间建立不同的距离。

  DOI：

  10.1021/jo101066c
• 作为产物：
  描述：

  氯甲酸苄酯 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 生成 benzyl (2-(((tert-butoxycarbonyl)amino)oxy)ethyl)carbamate
  参考文献：
  名称：

  Fluorescent Flippers for Mechanosensitive Membrane Probes

  摘要：

  In this report, fluorescent flippers are introduced to create planarizable pushpull probes with the mechanosensitivity and fluorescence lifetime needed for practical use in biology. Twisted pushpull scaffolds with large and bright dithienothiophenes and their S,S-dioxides as the first fluorescent flippers are shown to report on the lateral organization of lipid bilayers with quantum yields above 80% and lifetimes above 4 ns. Their planarization in liquid-ordered (Lo) and solid-ordered (So) membranes results in red shifts in excitation of up to +80 nm that can be transcribed into red shifts in emission of up to +140 nm by Forster resonance energy transfer (FRET). These unique properties are compatible with multidomain imaging in giant unilamellar vesicles (GUVs) and cells by confocal laser scanning or fluorescence lifetime imaging microscopy. Controls indicate that strong push-pull macrodipoles are important, operational probes do not relocate in response to lateral membrane reorganization, and two flippers are indeed needed to really swim, i.e., achieve high mechanosensitivity.

  DOI：

  10.1021/ja5107018

文献信息

• MODIFIED RELAXIN POLYPEPTIDES COMPRISING A PHARMACOKINETIC ENHANCER AND USES THEREOF
  申请人：Bristol-Myers Squibb Company

  公开号：US20180222960A1

  公开（公告）日：2018-08-09

  The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

  本公开涉及改良的Relaxin多肽，例如改良的人类Relaxin 2多肽，包括与药代增强剂相连的非自然编码氨基酸，并且这些多肽的治疗用途，例如用于治疗心血管疾病（如心力衰竭）和/或与纤维化相关的疾病。
• Oxazolidinone derivatives having a 7-membered heterocyclic ring
  申请人：Research Foundation Itsuu Laboratory

  公开号：EP2233484A2

  公开（公告）日：2010-09-29

  The present invention provides a compound of the formula: or a pharmaceutically acceptable salt or solvate thereof wherein Y1 is NRa, O, S, SO or SO2; Ring B is optionally substituted carbocycle or optionally substituted heterocycle.

  本发明提供了一种式化合物： 或其药学上可接受的盐或溶液 其中 Y1 是 NRa、O、S、SO 或 SO2； 环 B 是任选取代的碳环或任选取代的杂环。
• Fluorescent Flippers for Mechanosensitive Membrane Probes
  作者：Marta Dal Molin、Quentin Verolet、Adai Colom、Romain Letrun、Emmanuel Derivery、Marcos Gonzalez-Gaitan、Eric Vauthey、Aurélien Roux、Naomi Sakai、Stefan Matile

  DOI：10.1021/ja5107018

  日期：2015.1.21

  In this report, fluorescent flippers are introduced to create planarizable pushpull probes with the mechanosensitivity and fluorescence lifetime needed for practical use in biology. Twisted pushpull scaffolds with large and bright dithienothiophenes and their S,S-dioxides as the first fluorescent flippers are shown to report on the lateral organization of lipid bilayers with quantum yields above 80% and lifetimes above 4 ns. Their planarization in liquid-ordered (Lo) and solid-ordered (So) membranes results in red shifts in excitation of up to +80 nm that can be transcribed into red shifts in emission of up to +140 nm by Forster resonance energy transfer (FRET). These unique properties are compatible with multidomain imaging in giant unilamellar vesicles (GUVs) and cells by confocal laser scanning or fluorescence lifetime imaging microscopy. Controls indicate that strong push-pull macrodipoles are important, operational probes do not relocate in response to lateral membrane reorganization, and two flippers are indeed needed to really swim, i.e., achieve high mechanosensitivity.
• Synthesis of Aminooxy and <i>N</i>-Alkylaminooxy Amines for Use in Bioconjugation
  作者：Michael R. Carrasco、Carolina I. Alvarado、Scott T. Dashner、Amanda J. Wong、Michael A. Wong

  DOI：10.1021/jo101066c

  日期：2010.8.20

  Five Boc-protected aminooxy and N-alkylaminooxy amines have been synthesized in 60−95% overall yield using a common synthetic strategy from readily available two- and three-carbon Cbz-protected amino alcohols. The amines can be linked to biomolecules via amide formation and incorporated directly into peptoids via submonomer synthesis. Subsequent deprotection of the aminooxy and N-alkylaminooxy groups

  五种 Boc 保护的氨基氧基和N-烷基氨基氧基胺已使用常见的合成策略从现成的二碳和三碳 Cbz 保护的氨基醇合成，总产率为 60-95%。胺可以通过酰胺形成与生物分子连接，并通过亚单体合成直接结合到类肽中。随后氨基氧基和N-烷基氨基氧基的脱保护能够通过已建立的化学选择性连接方法与所需的目标分子缀合。合成的衍生物的范围允许在共轭分子之间建立不同的距离。