Tert-butyl [3-[(2-methylpropan-2-yl)oxycarbonyloxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl] carbonate | 1228552-14-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl [3-[(2-methylpropan-2-yl)oxycarbonyloxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl] carbonate
• 英文别名: tert-butyl [3-[(2-methylpropan-2-yl)oxycarbonyloxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl] carbonate
• CAS: 1228552-14-4
• 化学式: C₂₂H₃₃BO₈
• 分子量: 436.31
• InChiKey: ALIUKGHLPMMBPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.61
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Tert-butyl [3-[(2-methylpropan-2-yl)oxycarbonyloxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl] carbonate 在 Oxone 作用下， 以 水 、 丙酮 为溶剂， 反应 0.5h， 生成 di-tert-butyl 5-hydroxy-1,3-phenylene biscarbonate
  参考文献：
  名称：

  Iridium-catalyzed C–H activation/borylation/oxidation for the preparation of bis-protected phloroglucinol derivatives

  摘要：

  The preparation of bis-protected phloroglucinol derivatives from a range of protected resorcinol substrates is presented. Functionalization was achieved via a two-step, one-pot iridium-catalyzed C-H activation/borylation/oxidation protocol. Our system gave high conversions to the arylboronic esters and good yields of the desired phenols following subsequent oxidation. A range of common protecting group categories was studied including alkyl, silyl, ether and ester. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.049
• 作为产物：
  描述：

  Tert-butyl [3-[(2-methylpropan-2-yl)oxycarbonyloxy]phenyl] carbonate 、 联硼酸频那醇酯 在 (1,5-cyclooctadiene)(methoxy)iridium(I) dimer 、 4,4'-二叔丁基-2,2'-二吡啶 作用下， 以 2-甲基戊烷 为溶剂， 反应 18.0h， 生成 Tert-butyl [3-[(2-methylpropan-2-yl)oxycarbonyloxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl] carbonate
  参考文献：
  名称：

  Iridium-catalyzed C–H activation/borylation/oxidation for the preparation of bis-protected phloroglucinol derivatives

  摘要：

  The preparation of bis-protected phloroglucinol derivatives from a range of protected resorcinol substrates is presented. Functionalization was achieved via a two-step, one-pot iridium-catalyzed C-H activation/borylation/oxidation protocol. Our system gave high conversions to the arylboronic esters and good yields of the desired phenols following subsequent oxidation. A range of common protecting group categories was studied including alkyl, silyl, ether and ester. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.049

文献信息

• Iridium-catalyzed C–H activation/borylation/oxidation for the preparation of bis-protected phloroglucinol derivatives
  作者：Laura J. Marshall、Karl M. Cable、Nigel P. Botting

  DOI：10.1016/j.tetlet.2010.03.049

  日期：2010.5

  The preparation of bis-protected phloroglucinol derivatives from a range of protected resorcinol substrates is presented. Functionalization was achieved via a two-step, one-pot iridium-catalyzed C-H activation/borylation/oxidation protocol. Our system gave high conversions to the arylboronic esters and good yields of the desired phenols following subsequent oxidation. A range of common protecting group categories was studied including alkyl, silyl, ether and ester. (C) 2010 Elsevier Ltd. All rights reserved.