2-methyl-6-[5-methyl-4-(1-phenylpyrazol-4-yl)-1H-pyrazol-3-yl]-3-phenylmethoxyphenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methyl-6-[5-methyl-4-(1-phenylpyrazol-4-yl)-1H-pyrazol-3-yl]-3-phenylmethoxyphenol
• 化学式: C₂₇H₂₄N₄O₂
• 分子量: 436.513
• InChiKey: XWUAQWUKICAJFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SPECIFIC 2-(4-(PHENOXY)-1H-PYRAZOL-3-YL)PHENOL DERIVATIVES AS INHIBITORS OF C-MYC/DNA BINDING ACTIVITY FOR TREATING CANCER
  申请人：Northwestern University

  公开号：EP3426636B1

  公开（公告）日：2021-12-29
• SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS
  申请人：Northwestern University

  公开号：US20170253581A1

  公开（公告）日：2017-09-07

  Disclosed are substituted heterocycles compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.